中国病理生理杂志2024，Vol.40Issue(6)：1122-1127,1146,7.DOI:10.3969/j.issn.1000-4718.2024.06.019
肺类器官研究及应用进展
Progress in research and application of lung organoids
摘要
Abstract
In the field of biomedicine,two-dimensional(2D)cell lines and animal models have played an im-portant role in the study of cell pathways and drug targets.However,due to species differences between humans and other animals,and the lack of hierarchy,cellular diversity,and cell-cell or cell-matrix interactions,2D cell lines could not ful-ly reflect what cells actually look like in the human body.Organoids are three-dimensional(3D)in vitro culture models de-rived from autologous tissue stem cells,which make up for the defects of 2D culture and can simulate the structure and function of real human organs to a certain extent,providing new ideas for disease diagnosis and treatment.Among them,lung organoids(LO)are a typical case studying the development process of human lung and the generation principle of lung diseases.Relevant studies have provided help for the treatment of pulmonary fibrosis,lung cancer,lung injury and other diseases.This paper aims to summarize and analyze the research progress of lung organoids in recent years,and fur-ther summarize the application of LO in the diagnosis and treatment of lung diseases.关键词
肺类器官/肺疾病/干细胞Key words
lung organoids/lung diseases/stem cells分类
医药卫生引用本文复制引用
杨广平,房贺,刘晓彬,付忠华,朱峰..肺类器官研究及应用进展[J].中国病理生理杂志,2024,40(6):1122-1127,1146,7.基金项目
国家重点研发计划"干细胞及转化研究"重点专项(No.2019YFA0110601) （No.2019YFA0110601）
国家自然科学基金资助项目(No.91210452) （No.91210452）
上海市科技创新行动计划(No.22Y11900200) （No.22Y11900200）
