中国病理生理杂志2024，Vol.40Issue(6)：1141-1146,6.DOI:10.3969/j.issn.1000-4718.2024.06.022
含溴结构域蛋白4在心血管疾病发病机制中的研究进展
Progress in bromodomain-containing protein 4 in pathogenesis of cardiovascular diseases
摘要
Abstract
Bromodomain-containing protein 4(BRD4),a pivotal member of the bromodomain and extra-ter-minal domain(BET)family,is integral to the regulation of vital biological processes,including the cell cycle and gene ex-pression.Studies have identified extensive expression of BRD4 in cardiomyocytes and its influence on various signaling pathways.The dysregulation of BRD4 leads to significant alterations in these pathways,culminating in pathological states such as myocardial inflammation,fibrosis,oxidative stress,and hypertrophy.These changes are instrumental in the onset and progression of cardiovascular diseases.This review summarizes the advances in research on BRD4 and its inhibitors in the context of cardiovascular diseases,with a focus on providing insights for precise therapeutic interventions.关键词
心血管疾病/含溴结构域蛋白4/BRD4抑制剂/发病机制Key words
cardiovascular disease/bromodomain-containing protein 4/BRD4 inhibitor/pathogenesis分类
医药卫生引用本文复制引用
何磊,董泉彬,李菊香..含溴结构域蛋白4在心血管疾病发病机制中的研究进展[J].中国病理生理杂志,2024,40(6):1141-1146,6.基金项目
江西省重点研发计划项目(No.20202BBGL73069) （No.20202BBGL73069）
