34例非结核分枝杆菌病的临床病理特征分析OA北大核心CSTPCD

Objective:To explore the clinicopathological characteristics of non-tuberculous mycobacterial(NTM)disease.Methods:Clinical and pathological data from 34 NTM patients who were diagnosed and treated in Peking Union Medical College Hospital between March 1,2015 and December 31,2023 were retrospectively collected.All patients were divided into disseminated NTM disease group(14 cases)and non-disseminated NTM disease group(20 cases).The clinicopathological characteristics of these groups were analyzed and compared.Results:Twenty-two patients(64.71％,22/34)were infected with Mycobacterium avium/intracellular;6 patients(17.65％,6/34)were caused by Turtle/Mycobacterium abscessus infection,and 4 patients(11.76％,4/34)were infected with Mycobacterium kansasii.Histopathological examination revealed granulomatous lesions in 23 cases(67.65％,23/34).Of these,19 cases(82.61％,19/23)exhibited loosely arranged granuloma,7 cases(30.43％,7/23)showed suppurative granulomas,and basophilic necrosis was found in 5 cases(14.71％,5/34).Pink-stained caseous necrosis was reviewed in 4 cases(11.76％,4/34),and multinucleated giant cell reaction was observed in 18 cases(52.94％,18/34).Positive acid-fast staining was identified in 5 out of 21 cases examined(23.81％,5/21).Conclusion:The pathological features of NTM disease are diverse,with loosely arranged epithelioid granulomas being the most common finding.These granulomas are often accompanied by multinucleated giant cell reactions and suppurative granuloma.