中国当代儿科杂志2024，Vol.26Issue(6)：559-566,8.DOI:10.7499/j.issn.1008-8830.2309137
尘螨皮下免疫治疗应用于儿童过敏性哮喘疗效
Efficacy and safety of dust mite subcutaneous immunotherapy in children with allergic asthma:a prospective randomized controlled study
摘要
Abstract
Objective To investigate the efficacy and safety of subcutaneous immunotherapy(SCIT)using dust mites in children with allergic asthma.Methods In a prospective randomized controlled study,98 children with dust mite-induced allergic asthma were randomly divided into a control group(n=49)and an SCIT group(n=49).The control group received inhaled corticosteroid treatment,while the SCIT group additionally received a standardized three-year SCIT regimen.The two groups were compared based on peripheral blood eosinophil percentage,visual analogue score(VAS),total medication score,Asthma Control Test/Childhood Asthma Control Test scores,fractional exhaled nitric oxide(FeNO),and lung function before treatment,and at 6 months,1 year,2 years,and 3 years after treatment.Adverse reactions were recorded post-injection to evaluate the safety of SCIT.Results Compared with pre-treatment levels,the SCIT group showed a significant reduction in the percentage of peripheral blood eosinophils,VAS,total medication score,and FeNO,while lung function significantly improved,and asthma control levels were better 3 years after treatment(P<0.05).Compared with the control group,the SCIT group showed more significant improvement in all evaluated indicators 3 years after treatment(P<0.05).A total of 2 744 injections were administered,resulting in 157 cases(5.72%)of local adverse reactions and 4 cases(0.15%)of systemic adverse reactions,with no severe systemic adverse events.Conclusions SCIT is an effective and safe treatment for allergic asthma in children.关键词
皮下免疫治疗/过敏性哮喘/疗效/安全性/儿童Key words
Subcutaneous immunotherapy/Allergic asthma/Efficacy/Safety/Child引用本文复制引用
王雅妮,鲁思琪,陈海,李玉勤,卢红艳,朱慧,常明..尘螨皮下免疫治疗应用于儿童过敏性哮喘疗效[J].中国当代儿科杂志,2024,26(6):559-566,8.基金项目
江苏省卫生健康委2022年度医学科研立项项目(M2022043) （M2022043）
江苏省镇江市2023年度科技创新资金项目(SS2023012). （SS2023012）
