4～6岁阻塞性睡眠呼吸暂停低通气综合征患儿肠道代谢产物特征及临床价值分析OA北大核心CSTPCDMEDLINE
Characteristics and clinical value of intestinal metabolites in children aged 4-6 years with obstructive sleep apnea-hypopnea syndrome
目的 探究4～6岁阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患儿肠道代谢产物特征及其临床价值.方法 前瞻性纳入31例4～6岁OSAHS患儿作为试验组,24例4～6岁健康儿童作为对照组,记录相关临床指标.收集粪便标本,通过液-质联用非靶向代谢组学检测所有代谢产物.结果 共检测出206种代谢产物,主要为氨基酸及其衍生物.试验组儿童肠道代谢产物整体构成与对照组差异有统…查看全部>>
Objective To study the characteristics and clinical value of intestinal metabolites in children aged 4-6 years with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 31 children aged 4-6 years with OSAHS were prospectively enrolled as the test group,and 24 healthy children aged 4-6 years were included as the control group.Relevant clinical indicators were recorded.Fecal samples were collected,and non-targeted metabolomics analysis using liq…查看全部>>
陈悦;卢燕波;吴军华;邱海燕
宁波大学医学部,浙江宁波 315000||宁波市妇女儿童医院儿科,浙江宁波 315000宁波大学医学部,浙江宁波 315000||宁波市妇女儿童医院儿科,浙江宁波 315000宁波市妇女儿童医院儿科,浙江宁波 315000宁波市妇女儿童医院儿科,浙江宁波 315000
阻塞性睡眠呼吸暂停低通气综合征肠道代谢产物生物标志物代谢功能儿童
Obstructive sleep apnea-hypopnea syndromeIntestinal metaboliteBiomarkerMetabolic functionChild
《中国当代儿科杂志》 2024 (6)
575-583,9
浙江省医药卫生科技计划(2024KY1576)第一批宁波市临床医学研究中心依托单位(2019A21002)宁波市社会公益研究项目(2021S100)宁波市医学重点学科建设计划(2022-B17)宁波市医疗卫生高端团队项目(2022020405).
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