中国防痨杂志2024，Vol.46Issue(7)：799-807,9.DOI:10.19982/j.issn.1000-6621.20240096
144例老年利福平耐药肺结核患者治疗转归及影响因素分析
Analysis of treatment outcomes and influencing factors in 144 elderly patients with rifampicin drug-resistant pulmonary tuberculosis
摘要
Abstract
Objective:To analyze the treatment outcomes and influencing factors of elderly rifampicin drug-resistant pulmonary tuberculosis patients.Methods:A retrospective study was conducted,and clinical data of 144 elderly rifampicin drug-resistant pulmonary tuberculosis patients treated at the Anhui Chest Hospital from September 2020 to September 2023 were collected according to inclusion criteria.Treatment outcomes and influencing factors of patients were analyzed.Results:Among the 144 elderly drug-resistant pulmonary tuberculosis patients,65 cases(45.14％)had favorable treatment outcomes,including 51 cases(35.42％)cured and 14 cases(9.72％)completed treatment;79 cases(54.86％)had unfavorable treatment outcomes,including 7 cases(4.86％)getting treatment failure,57 cases(39.58％)lost to follow-up,and 15(10.42％)deaths,of which 7 were due to tuberculosis.Multifactor logistic regression analysis showed that body mass index(BMI)≥ 18.5(OR=0.131,95％C1:0.040-0.429,P＜0.001)and long-term supervision and management(OR=0.052,95％CI:0.013-0.204,P＜0.001)were protective factors for favorable outcomes,while comorbid diabetes(OR=3.266,95％CI:1.074-9.936,P=0.037)and gastrointestinal adverse reactions(OR=8.976,95％CI:2.582-31.205,P＜0.001)were risk factors for unfavorable outcomes.Conclusion:The cure rate of elderly rifampicin drug-resistant pulmonary tuberculosis in Anhui Province was low.Attention should be paid to elderly patients with comorbid diabetes,poor nutritional status,lack of long-term supervised medicine taking and management,and drug adverse reactions.Active control of blood sugar levels,management of adverse reactions,strengthening nutritional support and supervision management are necessary to further improve the cure rate.关键词
老年/结核,肺/抗药性,细菌/治疗结果/因素分析,统计学Key words
Elderly/Tuberculosis,pulmonary/Drug resistance,bacterium/Treatment outcome/Factor analysis,statistical分类
医药卫生引用本文复制引用
高磊,梁雅雪,刘盛盛,王华..144例老年利福平耐药肺结核患者治疗转归及影响因素分析[J].中国防痨杂志,2024,46(7):799-807,9.基金项目
2022年度安徽省卫生健康科研项目(AHWJ2022b040) Health Research Project of Anhui Province in 2022(AHWJ2022b040) （AHWJ2022b040）
