中国当代儿科杂志2024，Vol.26Issue(6)：605-610,6.DOI:10.7499/j.issn.1008-8830.2312017
miR-142在儿童自身免疫性甲状腺疾病中表达及与Th17/Treg失衡关系的研究
Expression of miR-142 and its relationship with Th17/Treg imbalance in children with autoimmune thyroid disease
摘要
Abstract
Objective To investigate the expression of microRNA-142(miR-142)in children with autoimmune thyroid disease(AITD)and its relationship with the imbalance of helper T cell 17(Th17)and regulatory T cell(Treg).Methods A total of 89 children hospitalized for AITD from January 2019 to December 2022 were prospectively selected as the study subjects,including 48 children with Graves'disease(GD group)and 41 children with Hashimoto's thyroiditis(HT group).Additionally,55 healthy children undergoing physical examinations during the same period were selected as the control group.The differences in serum miR-142,antithyroglobulin antibody(TGAb),antithyroperoxidase antibody(TPOAb),Th17/Treg,and interleukin-17(IL-17)expression were compared among the groups.Results The expression of miR-142,TPOAb,TGAb,Th17,Th17/Treg,and IL-17 in the GD group and HT group was higher than that in the control group,while Treg was lower than that in the control group(P<0.05).Pearson correlation analysis revealed that in the GD group,miR-142 was positively correlated with TPOAb,TGAb,Th17,Th17/Treg,and IL-17(r=0.711,0.728,0.785,0.716,0.709,respectively;P<0.001)and negatively correlated with Treg(r=-0.725,P<0.001);in the HT group,miR-142 was positively correlated with TPOAb and TGAb(r=0.752,0.717,respectively;P<0.001).Conclusions miR-142 is highly expressed in children with AITD,and its expression may be related to the Th17/Treg imbalance in children with GD.关键词
自身免疫性甲状腺疾病/miR-142/免疫平衡/辅助性T细胞17/调节性T细胞/儿童Key words
Autoimmune thyroid disease/miR-142/Immune balance/Helper T cell 17/Regulatory T cell/Child引用本文复制引用
罗平,辛艳梅,郭渠莲,沈兴..miR-142在儿童自身免疫性甲状腺疾病中表达及与Th17/Treg失衡关系的研究[J].中国当代儿科杂志,2024,26(6):605-610,6.基金项目
四川省科技计划资助(2022YFS0622) （2022YFS0622）
泸州市人民政府-西南医科大学科技战略合作项目(2023LZXNYDJ047). （2023LZXNYDJ047）
