中国防痨杂志2024，Vol.46Issue(7)：839-844,6.DOI:10.19982/j.issn.1000-6621.20240118
G蛋白偶联受体在宿主抗结核分枝杆菌感染中的功能及作用机制
The function and mechanism of G protein-coupled receptors in host against Mycobacterium tuberculosis infection
摘要
Abstract
G protein-coupled receptors(GPCRs)play a critical role in maintaining normal physiological functions and intracellular homeostasis in the human body.Dysregulation of GPCRs and their downstream signaling pathways are significant markers in the development and progression of various diseases.In recent years,the prevention and treatment of tuberculosis(TB)have faced increasingly severe challenges,highlighting the urgent need for the development of new anti-TB drugs that are safe,affordable,and sensitive.Among these,novel antimicrobial drugs based on host-directed therapeutic strategies have garnered widespread attention.GPCRs,as receptors that regulate host immune expression,can serve as potential therapeutic targets for host-directed anti-TB treatment.However,researches on GPCRs as important drug targets in the field of TB are still insufficient.The author summarizes the recently discovered functions of GPCRs in host cell responses to Mycobacterium tuberculosis infection.It systematically reviews the key roles and molecular mechanisms of chemokine receptor-like GPCRs,orphan GPCRs,and other GPCRs in regulating host cell signal transduction,providing a basis for the development of GPCR-based anti-TB drugs.关键词
受体,G-蛋白偶联/巨噬细胞/分枝杆菌,结核/感染Key words
Receptors,G-protein-coupled/Macrophages/Mycobacterium tuberculosis/Infection分类
基础医学引用本文复制引用
刘浩瀚,马子淳,逄宇,李姗姗..G蛋白偶联受体在宿主抗结核分枝杆菌感染中的功能及作用机制[J].中国防痨杂志,2024,46(7):839-844,6.基金项目
National Natural Science Foundation of China(82202530) 国家自然科学基金(82202530) （82202530）
