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双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究

樊雨薇姜泓饶红萍邱建武魏贤张亚昱曾纪斌赵常亮许伟鹏王凡员丽张伊佳杨秀芳李薇林霓阳陈倩夏昌顺钟鑫琪崔其亮温和梅晏红沈蔚丁月琴龙运峰张志钢李桂芳

中国当代儿科杂志2024，Vol.26Issue(6)：611-618,8.

中国当代儿科杂志2024，Vol.26Issue(6)：611-618,8.DOI:10.7499/j.issn.1008-8830.2312005

双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究

Risk factors for bronchopulmonary dysplasia in twin preterm infants:a multicenter study

樊雨薇 ¹姜泓 ²饶红萍 ³邱建武 ⁴魏贤 ⁵张亚昱 ⁶曾纪斌 ⁷赵常亮 ⁸许伟鹏 ⁹王凡 ¹⁰员丽 ¹¹张伊佳 ¹²杨秀芳 ¹³李薇 ¹⁴林霓阳 ¹⁵陈倩 ¹夏昌顺 ¹钟鑫琪 ¹崔其亮 ¹温和梅 ¹⁶晏红 ¹⁷沈蔚 ¹⁸丁月琴 ¹⁹龙运峰 ²⁰张志钢 ²¹李桂芳²²

作者信息

1. 广州医科大学附属第三医院新生儿科/广东省产科重大疾病重点实验室/广东省妇产疾病临床医学研究中心/粤港澳母胎医学高校联合实验室,广东广州 510150
2. 延安大学附属医院新生儿科,陕西延安 716000
3. 惠州市中心人民医院新生儿科,广东惠州 516001
4. 汕头大学医学院附属粤北人民医院新生儿科,广东韶关 512026
5. 武汉科技大学附属孝感医院新生儿科,湖北孝感 432000
6. 内蒙古医科大学附属医院新生儿科,内蒙古呼和浩特 010050
7. 汕头大学医学院第二附属医院新生儿科,广东汕头 515041
8. 包钢集团第三职工医院新生儿科,内蒙古包头 014010
9. 暨南大学附属第一医院新生儿科,广东广州 510630
10. 兰州大学第二医院,甘肃兰州 730000
11. 新乡市中心医院新生儿科,河南新乡 453000
12. 北京大学第三医院儿科,北京 100191
13. 中山市人民医院新生儿科,广东中山 528400
14. 东莞市滨海湾中心医院新生儿科,广东东莞 523808
15. 汕头大学医学院第一附属医院新生儿科,广东汕头 515041
16. 四川锦欣妇女儿童医院新生儿科,四川成都 610011
17. 贵州医科大学附属医院新生儿科,贵州贵阳 550001
18. 厦门大学附属妇女儿童医院新生儿科,福建厦门 361003
19. 南方医科大学附属东莞医院新生儿科,广东东莞 523000
20. 邵阳学院附属第一医院新生儿科,湖南邵阳 422000
21. 广东省第二人民医院新生儿科,广东广州 511000
22. 沧州市人民医院新生儿科,河北沧州 061000
折叠

摘要

Abstract

Objective To investigate the risk factors for bronchopulmonary dysplasia(BPD)in twin preterm infants with a gestational age of<34 weeks,and to provide a basis for early identification of BPD in twin preterm infants in clinical practice.Methods A retrospective analysis was performed for the twin preterm infants with a gestational age of<34 weeks who were admitted to 22 hospitals nationwide from January 2018 to December 2020.According to their conditions,they were divided into group A(both twins had BPD),group B(only one twin had BPD),and group C(neither twin had BPD).The risk factors for BPD in twin preterm infants were analyzed.Further analysis was conducted on group B to investigate the postnatal risk factors for BPD within twins.Results A total of 904 pairs of twins with a gestational age of<34 weeks were included in this study.The multivariate logistic regression analysis showed that compared with group C,birth weight discordance of>25%between the twins was an independent risk factor for BPD in one of the twins(OR=3.370,95%CI:1.500-7.568,P<0.05),and high gestational age at birth was a protective factor against BPD(P<0.05).The conditional logistic regression analysis of group B showed that small-for-gestational-age(SGA)birth was an independent risk factor for BPD in individual twins(OR=5.017,95%CI:1.040-24.190,P<0.05).Conclusions The development of BPD in twin preterm infants is associated with gestational age,birth weight discordance between the twins,and SGA birth.

关键词

支气管肺发育不良/危险因素/多中心研究/双胎儿/早产儿

Key words

Bronchopulmonary dysplasia/Risk factor/Multicenter study/Twins/Preterm infant

引用本文复制引用

樊雨薇,姜泓,饶红萍,邱建武,魏贤,张亚昱,曾纪斌,赵常亮,许伟鹏,王凡,员丽,张伊佳,杨秀芳,李薇,林霓阳,陈倩,夏昌顺,钟鑫琪,崔其亮,温和梅,晏红,沈蔚,丁月琴,龙运峰,张志钢,李桂芳..双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究[J].中国当代儿科杂志,2024,26(6):611-618,8.

基金项目

广州市科技计划项目(2023A03J0382). （2023A03J0382）

中国当代儿科杂志

OA北大核心CSTPCDMEDLINE

ISSN：1008-8830

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