7日龄住院早产儿甲状腺功能影响因素及参考值范围探讨OA北大核心CSTPCDMEDLINE

Objective To investigate the influencing factors and reference ranges for thyroid function in preterm infants at the age of 7 days,with the aim of avoiding unnecessary clinical reexamination and intervention.Methods A retrospective analysis was performed for the data of 685 preterm infants from January 2020 to January 2023.According to gestational age and birth weight,they were divided into a high-risk group(gestational age<34 weeks or birth weight<2 000 g;228 infants)and a low-risk group(gestational age≥34 weeks and birth weight≥2 000 g;457 infants).The influencing factors for thyroid function were analyzed,and 95%reference range was calculated.Results Gestational age,birth weight,birth season,sex,and assisted reproduction were the influencing factors for thyroid function(P<0.05).For the preterm infants in the high-risk group,the reference ranges of free triiodothyronine(FT3),free thyroxine(FT4),total triiodothyronine(TT3),total thyroxine(TT4),and thyroid stimulating hormone(TSH)were 2.79-5.40 pmol/L,8.80-25.64 pmol/L,0.80-2.15 nmol/L,50.06-165.09 nmol/L,and 0.80-18.57 μIU/mL,respectively.For those in the low-risk group,the reference ranges of these indicators were 3.08-5.93 pmol/L,11.17-26.24 pmol/L,1.02-2.27 nmol/L,62.90-168.95 nmol/L,and 0.69-13.70 μIU/mL,respectively.FT3,FT4,TT3,and TT4 were positively correlated with gestational age(P<0.05);FT3,FT4,TT3,and TT4 were positively correlated with birth weight(P<0.05);TSH was negatively correlated with birth weight(P<0.05).Conclusions Thyroid function in preterm infants at the age of 7 days is affected by the factors such as gestational age and birth weight,and the reference ranges of thyroid function in preterm infants at the age of 7 days should be established based on gestational age and birth weight.