中国口腔种植学杂志2024，Vol.29Issue(3)：218-223,6.DOI:10.12337/zgkqzzxzz.2024.06.005
先天缺牙致病基因的相关研究进展
Progress in research on genes associated with tooth agenesis
摘要
Abstract
Tooth agenesis,a prevalent oral disease,remains partially elusive in terms of its underlying pathogenic mechanism.Recent breakthroughs have elucidated a series of pathogenic genes associated with this condition,whose encoded proteins play key roles in regulating and guiding normal tooth germ development through essential signaling pathways.This review focuses on genes related to congenital tooth agenesis and their involvement in the signaling pathways of tooth developrnet.As research progreses,especialy through the use of model animal,insights into the pathogenic processes of this developmental anomaly may lead to effective strategies for treating congenital tooth agenesis by modulating the function of these genes or repairing defects in signal transmission.Moreover,this article also discusses the clinical characteristics of congenital tooth agenesis-causing genes observed in human patients and explores the potential link between these genes and the occurrence of tumors.关键词
先天缺牙/致病机制/成牙信号Key words
Tooth agenesis/Pathogenesis/Odontogenesis signaling引用本文复制引用
张晗,孙瑶..先天缺牙致病基因的相关研究进展[J].中国口腔种植学杂志,2024,29(3):218-223,6.基金项目
国家自然科学基金优秀青年科学基金(81822012) （81822012）
上海市科委2020 年度"科技创新行动计划"实验动物研究 National Natural Science Foundation of China(81822012) （81822012）
Shanghai Experimental Animal Research Project of Science and Technology Innovation Action Plan(201409006400) （201409006400）
Shanghai Academic Leader of Science and Technology Innovation Action Plan(20XD1424000) （20XD1424000）
