中国临床药理学与治疗学2024，Vol.29Issue(7)：831-840,10.DOI:10.12092/j.issn.1009-2501.2024.07.014
白花蛇舌草-半枝莲药对治疗胃癌的物质基础和作用机制研究进展
Research progress on material basis and mechanism of Hedyotis Dif-fusa-Scutellaria Barbata Herb Pair in the treatment of gastric cancer
摘要
Abstract
Gastric cancer is one of the most com-mon malignant tumors in the digestive system,which often occurs in middle-aged and elderly peo-ple.Traditional Chinese medicine recognizes gastric cancer as a kind of tumor characterized by fluid de-ficiency,heat accumulation and the growing bind-ing of toxins in the stomach.It is commonly treated with heat-clearing and detoxifying drugs in clinical practice.Hedyotis diffusa-Scutellaria barbata herb pair(HS)has the effects of clearing heat and detoxi-fying,promoting blood circulation,resolving car-buncle and expulsing boil,anti-inflammatory and analgesic,which are consistent with the etiology and pathogenesis of gastric cancer,therefore,it can be used for the treatment of gastric cancer.Modern pharmacological researches have con-firmed that HS can play an anti-gastric cancer role by inducing cell apoptosis,inhibiting cell prolifera-tion,inhibiting angiogenesis,improving immune mi-croenvironment and down-regulating telomerase activity.Herein,this review summarizes the active ingredients and related mechanism responsible for the anti-gastric cancer effect of HS,which will pro-vide the theoretical basis for its clinical use and the development of new drugs against gastric cancers.关键词
白花蛇舌草/半枝莲/药对/胃癌/药理机制Key words
Hedyotis diffusa/Scutellaria barbata/drug pair/gastric cancer/pharmacological mecha-nism分类
医药卫生引用本文复制引用
张晓威,王楠,代梦格,刘瑞娟,马亭..白花蛇舌草-半枝莲药对治疗胃癌的物质基础和作用机制研究进展[J].中国临床药理学与治疗学,2024,29(7):831-840,10.基金项目
河南省科技研发计划联合基金(232301420058) （232301420058）
