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SPRED1参与银屑病发病的重要环节OA北大核心CSTPCD

SPRED1 involved in a key node pathogenesis of psoriasis

中文摘要英文摘要

银屑病是一种常见的免疫介导的、多种遗传和环境危险因素共同作用的炎症性皮肤病.异常的血管增生、角质形成细胞的过度增殖、多种免疫细胞浸润是银屑病的主要病理特征.MAPK信号通路参与银屑病的发病,SPRED1已经在其他疾病中被证明是MAPK信号通路的主要负调控因子.本文主要对SPRED1在银屑病发病中可能的作用进行综述,以期为银屑病发病机制提供新见解,为其治疗提供新方向.

Psoriasis is a common immune-mediated inflammatory skin disease with multiple genetic and environmental risk factors.Abnormal vascular hyperplasia,excessive proliferation of keratinocytes and infiltration of various immune cells are the main pathological features.MAPK signaling pathway is involved in the pathogenesis of psoriasis,and SPRED1 has been proved to be a ma-jor negative regulator of MAPK signaling pathway in many diseases.This article reviews the possible role of SPRED1 in the pathogene-sis of psoriasis,in order to provide new insights into the pathogenesis of psoriasis and new directions for the treatment.

杨旭燕;李俊琴;牛旭平;成彦蓉;李新华

山西医科大学第九临床医学院,太原 030009山西医科大学附属太原中心医院皮肤科免疫性皮肤病干细胞山西省重点实验室,太原 030009

临床医学

银屑病细胞增殖血管增生SPRED1MAPK信号通路

PsoriasisCell proliferationProliferated vascularSPRED1MAPK signal pathway

《中国免疫学杂志》 2024 (006)

1320-1323 / 4

山西省医学重点科研项目(2020XM20).

10.3969/j.issn.1000-484X.2024.06.034

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