中国免疫学杂志2024，Vol.40Issue(6)：1335-1344,封3,11.DOI:10.3969/j.issn.1000-484X.2024.06.037
IL-33的免疫调控作用
Immunomodulatory effects of IL-33
柳人莉 1刘利萍 2魏超杰 2李冬2
作者信息
- 1. 空军军医大学第一附属医院临床免疫科,西安 710005
- 2. 吉林大学基础医学院免疫学系,长春 130000
- 折叠
摘要
Abstract
IL-33 is a member of the IL-1 cytokine superfamily.It is a key regulator of pathological inflammation,immune ho-meostasis and fibrosis.IL-33 receptor ST2 is expressed on the surface of all innate immune cells,as well as some subtypes of B and T cells.IL-33 is a dual-function protein.Under normal circumstances,the N-terminal part of IL-33 resides in the nucleus of its ex-pressed cells and is released as a cytokine to exert immunomodulatory properties when cells are damaged or necrotic.Different expres-sion forms of IL-33 are located differently and may play different immunological roles.The immunological effects of IL-33 are highly di-verse.The cytokine IL-33 plays an amplifying and enhancing role in the innate immune response,while the full-length(FL)IL-33 stored in the nucleus inhibits inflammation by binding to NF-κB.IL-33/ST2 signaling plays a key role in both innate and acquired im-mune responses.In innate immunity,IL-33 and group 2 innate lymphocytes(ILC2)provide an important axis for rapid immune re-sponse and tissue homeostasis.In acquired immunity,IL-33 interacts with dendritic cells,Th2 cells,follicular helper T cells(Tfh)and regulatory T cells(Tregs).IL-33/ST2 signaling triggers pro-tumor or anti-tumor immune responses in different cell types in auto-crine and paracrine ways.In addition,the interaction between IL-33 and mitochondrial metabolism is also one of the potential mecha-nisms affecting the immune system.关键词
IL-33/FLIL-33/MIL-33/免疫调节/肿瘤免疫/代谢Key words
IL-33/FLIL-33/MIL-33/Immune regulation/Tumor immunity/Metabolize分类
医药卫生引用本文复制引用
柳人莉,刘利萍,魏超杰,李冬..IL-33的免疫调控作用[J].中国免疫学杂志,2024,40(6):1335-1344,封3,11.
