中国体外循环杂志2024，Vol.22Issue(3)：210-217,8.DOI:10.13498/j.cnki.chin.j.ecc.2024.03.09
A型主动脉夹层术后急性心肌梗死相关危险因素的套索回归分析
LASSO regression analysis of risk factors for postoperative acute myocardial infarction in type A aortic dissection patients
摘要
Abstract
Objective To investigate the potential risk factors associated with postoperative acute myocardial infarction(PAMI)in individuals diagnosed with type A aortic dissection(TAAD).Additionally,the study aims to develop a predictive model to assess the likelihood of PAMI in these patients following surgical intervention.Methods A retrospective analysis was performed on the clinical data of patients diagnosed with TAAD who underwent surgical treatment at Beijing Anzhen Hospital between January 2018 and October 2022.The primary outcome of interest was PAMI.A random allocation resulted in 70%of the patients being assigned to a training set,while the remaining 30%were assigned to a validation set.LASSO regression was employed in the training set to identify potential risk factors,and subsequently,a model was constructed.A column chart was generated to visually represent the findings.The model's discrimination and calibration were then assessed using the validation set.Results In this study of 1206 patients,6.9%experienced endpoint events.LASSO regression analysis identified several important factors for PAMI in TAAD,including coronary hypoperfusion,PT,FDP,amylase,surgery time and cardiopulmonary bypass time.The model based on these factors had good discrimination in the training set(C-index of 0.843)and high accuracy.In the validation set,the model had a C-index of 0.845.The calibration curve showed that the predicted and observed risks aligned for patients with a predicted risk below 50%.Conclusion The study's predictive model for PAMI in TAAD is effective in helping doctors intervene early and improve patient prognosis.关键词
A型主动脉夹层/术后急性心肌梗死/心肌保护/预测模型Key words
Type A aortic dissection/Postoperative acute myocardial infarction/Myocardial protection/Prediction model引用本文复制引用
张浩,贾博,乔环宇,杨波,杨璟,黑飞龙,侯晓彤,朱俊明,刘永民..A型主动脉夹层术后急性心肌梗死相关危险因素的套索回归分析[J].中国体外循环杂志,2024,22(3):210-217,8.基金项目
北京市科委项目(Z191100006619094) （Z191100006619094）
