3.0T超导磁共振成像和单核细胞与高密度脂蛋白比值、成纤维细胞生长因子与糖尿病周围神经病变的关系OACSTPCD

Objective:To explore the correlation between 3.0T superconducting magnetic resonance imaging(MRI),fibroblast growth factor 21(FGF21),monocyte to high density lipoprotein ratio(MHR)and diabetes peripheral neuropathy(DPN).Methods:A total of 80 patients with type 2 diabetes mellitus(T2DM)who were diagnosed and treated in Affiliated Traditional Chinese Medical Hospital of Xinjiang Medical University from January 2021 to December 2022 were selected as the study objects,and they were divided into DPN group(44 cases)and non-diabetic peripheral neuropathy(NDPN group)(36 cases)according to whether combined with DPN.Both two groups adopted 3.0T superconducting MRI to undergo examination by using the technique of magnetic resonance(MR)diffusion tensor imaging,and the enzyme-linked immunosorbent assay(ELISA)was used to detect serum FGF21 and MHR levels.The differences of fractional anisotropy(FA)of optical nerve,mean diffusivity(MD),maximum eigenvalue(λ∥),middle eigenvalue(λ⊥),serum FGF21 and MHR levels of the detection parameters of MR diffusion tensor imaging between two groups were compared.Spearman rank correlation analysis was adopted to explore the correlation between the parameters of MR diffusion tensor imaging and the levels of serum FGF21,MHR and DPN.Results:There were not statistically significant differences in gender and body mass index(BMI)between the two groups(P>0.05),while the age and course of disease in the DPN group were significantly higher than those in the NDPN group,with a statistically significant differences(t=5.039,7.852,P<0.05),respectively.The FA value of the DPN group was significantly lower than that of the NDPN group,and the MD,λ∥,λ⊥ values of the DPN group were significantly higher than those of the NDPN group(t=8.934,10.459,12.233,4.640,P<0.05),respectively.The serum levels of FGF21 and MHR in the DPN group were significantly higher than those in the NDPN group(t=3.286,24.509,P<0.05),respectively.Spearman correlation results showed that age,course of disease,MD value,λ∥ value,λ⊥ value,FGF21 and MHR levels significantly positively correlated with DPN(r=0.458,0.666,0.836,0.799,0.445,0.282,0.864,P<0.05),respectively,while FA significantly negatively correlated with DPN(r=-0.753,P<0.05).Conclusion:The related parameters of MR diffusion tensor imaging,as well as the FGF21 and MHR levels,significantly correlated with DPN,and the age and course of disease of patients are also related to the occurrence of DPN,which need cause clinical attention.