中国实用儿科杂志2024，Vol.39Issue(6)：425-432,8.DOI:10.19538/j.ek2024060605
系统性自身炎症性疾病治疗进展
Progress in the treatment of systemic autoinflammatory diseases
摘要
Abstract
Systemic autoinflammatory diseases(SAIDs)are a group of genetic disorders characterized by recurrent or persistent inflammatory responses and multi-system involve-ment,where the innate immune system plays a major role in disease pathogenesis.Although pathway-directed targeted therapies such as JAK inhibitors,IL-1 pathway inhibitors,and TNF inhibitors have achieved good response in some SAIDs.New targets and treatment strategies,powered by the understanding of disease mechanisms,the discovery of new genes,and the proposal of new classifications,are continuously applied in clinical practice and research.This article reviews the progress in the treatment of SAIDs in the past three years,introduces the updates in SAIDs treatment,and aims to promote the recognition,diagnosis,treatment,and research of such diseases in the future.关键词
自身炎症/靶向治疗/造血干细胞移植/基因治疗/个体化治疗Key words
autoinflammation/targeted therapy/hemato-poietic stem cell transplantation/gene therapy/personalized treatment分类
医药卫生引用本文复制引用
高思豪,宋红梅..系统性自身炎症性疾病治疗进展[J].中国实用儿科杂志,2024,39(6):425-432,8.基金项目
国家重点研发计划(2021YFC2702001) （2021YFC2702001）
北京协和医院中央高水平医院临床科研专项(2022-PUMCH-B-079) （2022-PUMCH-B-079）
