中国实用儿科杂志2024，Vol.39Issue(6)：432-438,7.DOI:10.19538/j.ek2024060606
炎症小体相关自身炎症性疾病研究进展
Research progress of inflammasome-associated autoinflammatory diseases
摘要
Abstract
The inflammasome is a macromolecular multi-protein complex in cells,and its activation can regulate the activation of cysteine aspartic protease-1(CASP1),promote the activation and secretion of IL-1β and IL-18,and cause inflammation in the body.In recent years,researchers have conducted extensive studies on the molecular composition and activation mechanisms of different inflammasomes,and a variety of inflammasome molecules have been characterized,among which the self-activating mutations of four inflamm-asome can lead to single-gene autoinflammatory diseases in humans.This review focuses on the research progress of the pathogenesis,clinical manifestations and treatment of NLRP1,CARD8,NLRP3,NLRC4 and Pyrin inflammasome-related autoinflammatory diseases.关键词
自身炎症性疾病/炎症小体/炎症小体病Key words
autoinflammatory diseases/inflammasome/infla-mmasomapathies分类
医药卫生引用本文复制引用
吴俊峰,唐雪梅..炎症小体相关自身炎症性疾病研究进展[J].中国实用儿科杂志,2024,39(6):432-438,7.基金项目
国家重点研发计划(2021YFC2702003) （2021YFC2702003）
重庆市教委科学技术研究项目(KJQN202200418) （KJQN202200418）
国家儿童健康与疾病临床医学研究中心临床医学研究一般项目(NCRCCHD-2022-YP-07) （NCRCCHD-2022-YP-07）
