首页|期刊导航|中华医学杂志（英文版）|Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

Jiacheng Li Ruopu Li Xue Bai Wenlong Zhang Yu Nie Shengshou Hu

中华医学杂志（英文版）2024，Vol.137Issue(11)：1351-1359,9.

中华医学杂志（英文版）2024，Vol.137Issue(11)：1351-1359,9.DOI:10.1097/CM9.0000000000003088

Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3

Jiacheng Li ¹Ruopu Li ²Xue Bai ²Wenlong Zhang ²Yu Nie ²Shengshou Hu²

作者信息

1. State Key Laboratory of Cardiovascular Disease,Fuwai Hospital and Cardiovascular Institute,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China||Department of Obstetrics and Gynecology,Beijing Advanced Innovation Center for Genomics,Third Hospital,School of Life Sciences,Peking University,Beijing 100871,China
2. State Key Laboratory of Cardiovascular Disease,Fuwai Hospital and Cardiovascular Institute,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China
折叠

摘要

关键词

Liver fibrosis/CRISPRa/Cell reprogramming/Transcriptional activation/Hepatocytes

Key words

Liver fibrosis/CRISPRa/Cell reprogramming/Transcriptional activation/Hepatocytes

引用本文复制引用

Jiacheng Li,Ruopu Li,Xue Bai,Wenlong Zhang,Yu Nie,Shengshou Hu..Direct reprogramming of fibroblasts into functional hepatocytes via CRISPRa activation of endogenous Gata4 and Foxa3[J].中华医学杂志（英文版）,2024,137(11):1351-1359,9.

基金项目

This work was supported by the grants from the National Key Research and Development Program of China(No.2019YFA0801500),National High Level Hospital Clini-cal Research Funding(No.2023-GSP-ZD-2-01),and the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-008). （No.2019YFA0801500）

中华医学杂志（英文版）

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ISSN：0366-6999

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