中国医学装备2024，Vol.21Issue(6)：101-105,5.DOI:10.3969/j.issn.1672-8270.2024.06.020
序贯性血液净化机治疗中毒所致的多器官功能障碍的临床效果及安全性评估
Clinical efficacy and safety assessment of sequential blood purifier in the treatment of multiple organ dysfunction caused by poisoning
摘要
Abstract
Objective:To explore and analyze the clinical efficacy and safety assessment of sequential blood purifier in the treatment of poisoning-induced multiple organ dysfunction syndrome(MODS).Methods:From May 2020 to February 2022,a total of 110 patients with MODS caused by poisoning who admitted to the First Affiliated Hospital of Xinjiang Medical University were selected.They were randomly divided into a sequential blood purification group and a single blood purification group,with 55 patients in each group.Nutritional metabolism indicators,function indicators of intestinal barrier,scores of Acute Physiology and Chronic Health Evaluation II(APACHE II),system of Multiple Organ Dysfunction Score(MODS)early prediction scores,and length of stay in Intensive Care Unit(ICU)between two groups were compared.At the same time,the incidence of complications during different blood purification treatments was also recorded.Results:After 7 days of treatment,the higher hemoglobin(Hb),albumin(ALB),cystatin A(PAB),and total cholesterol(TC)levels of sequential blood purification group were significantly higher than those of single blood purification group,while alanine aminotransferase(ALT)and triglycerides(TG)were significantly lower than that of single blood purification group(t=4.454,4.474,51.358,13.22,2.035,2.195,P<0.05),respectively.There were no significant differences in potassium(K+)and sodium(Na+)levels between the two groups after 7 days of treatment(P>0.05).Additionally,glutamate and glutamine levels of sequential blood purification group were significantly higher than those of single blood purification group,while L/M ratio was significantly lower than that of single blood purification group after 7 days of treatment,with statistically significant differences(t=32.83,3.435,4.132,P<0.05),respectively.The APACHEII score and MODS score of sequential blood purification group were significantly lower than those of single blood purification group,and the ICU length of stay was significantly shorter than that of single blood purification group after 7 days of treatment,with statistically significant differences(t=4.438,4.481,7.421,P<0.05),respectively.The incidence of complication of sequential blood purification group was significantly lower than that of single blood purification group,with statistical significance(x2=5.238,P<0.05).Conclusion:Compared to single blood purification therapy,sequential blood purification therapy is able to more effectively promote and regulate nutritional metabolism indicators,and improve intestinal barrier function in patients with poisoning-induced multiple organ dysfunction syndrome,which has better recovery outcomes,and lower incidence of complications,and shorter ICU length of stay.关键词
中毒/多器官功能障碍综合征(MODS)/单种血液净化/序贯性血液净化/营养代谢/肠道屏障功能/并发症Key words
Poisoning/Multiple organ dysfunction syndrome(MODS)/Single blood purification/Sequential blood purification/Nutrient metabolism/Intestinal barrier function/Complication分类
医药卫生引用本文复制引用
徐静,赵敏,姜薇薇,于蕾,肖克来提·霍加合买提..序贯性血液净化机治疗中毒所致的多器官功能障碍的临床效果及安全性评估[J].中国医学装备,2024,21(6):101-105,5.基金项目
新疆维吾尔自治区自然科学基金(2022D01C226) Xinjiang Uyghur Autonomous Region Natural Science Foundation(2022D01C226) （2022D01C226）
