栀子苷调节AMPK/SIRT1/NF-κB信号通路对急性呼吸窘迫综合征大鼠肺损伤的影响OA北大核心CSTPCD
Impact of geniposide on lung injury in rats with acute respiratory distress syndrome by regulating AMPK/SIRT1/NF-κB signaling pathway
目的:探讨栀子苷(GE)通过调节AMP活化蛋白激酶(AMPK)/沉默信息调节因子1(SIRT1)/核因子κB(NF-κB)信号通路对急性呼吸窘迫综合征(ARDS)大鼠肺损伤的影响.方法:通过气管滴注脂多糖(LPS)方法建立ARDS大鼠模型.将建模后的50只大鼠随机分为ARDS组、GE低剂量(GE-L,12.5 mg/kg GE)组、GE中剂量(GE-M,25 mg/kg GE)组、GE高剂量(GE-H,50 mg/kg GE)组、GE-H+Com…查看全部>>
Objective:To investigate the impact of geniposide(GE)on lung injury in rats with acute respiratory distress syn-drome(ARDS)by regulating AMP-activated protein kinase(AMPK)/silencing information regulator 1(SIRT1)/nuclear factor κB(NF-κB)signaling pathway.Methods:The ARDS rat model was established by tracheal instillation of lipopolysaccharide(LPS).Fifty rats after modeling were randomly group into ARDS group,GE low-dose(GE-L,12.5 mg/kg GE)group,GE medi…查看全部>>
孙立燕;张海燕;刘泽茹;尹庆卫
山东省潍坊市中医院重症医学科,潍坊 261041北京大学人民医院急诊科,北京 100044济宁医学院附属医院呼吸内科,济宁 272007山东省潍坊市中医院重症医学科,潍坊 261041
临床医学
栀子苷急性呼吸窘迫综合征AMPK/SIRT1/NF-κB信号通路肺损伤
GeniposideAcute respiratory distress syndromeAMPK/SIRT1/NF-κB signaling pathwayLung injury
《中国免疫学杂志》 2024 (6)
1142-1146,1152,6
潍坊市科技发展计划基金项目(2019YX056)潍坊市卫生健康委员会中医药科研项目(2019-04-083).
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