中国免疫学杂志2024，Vol.40Issue(6)：1197-1202,6.DOI:10.3969/j.issn.1000-484X.2024.06.014
LUNX基因作为与免疫细胞浸润相关的非小细胞肺癌预后生物标志物
LUNX gene serve as a prognostic biomarker for non-small cell lung cancer associated with immune cell infiltration
摘要
Abstract
Objective:To investigate whether the lung specific X protein(LUNX)gene can serve as a prognostic biomarker for non-small cell lung cancer related to immune cell infiltration.Methods:A total of 280 non-small cell lung cancer patients admitted to Hengshui People's Hospital from January 2020 to January 2023 were selected to detect the expression of LUNX gene in cancer tissue and adjacent tissues,and to analyze the relationship between LUNX gene and immune cell infiltration and prognosis survival status in the tumor microenvironment.Results:Compared with adjacent tissues,the expression level and positive rate of LUNX gene in non-small cell lung cancer tissue were increased,which were related to differentiation degree,lymph node metastasis and tumor staging(P<0.05).GEPIA database analysis showed that the LUNX gene was only slightly expressed or not expressed in other tissues,while its expression was elevated in LUAD and LUSC(P<0.05).The copy number of LUNX gene and LUNX gene were related to the level of immune cell infiltration(P<0.05).Survival analysis showed that high expression of the LUNX gene was associated with patient survival prognosis(P<0.05).Conclusion:The LUNX gene is specifically expressed in non-small cell lung cancer tissue,affecting the level of immune cell infiltration in non-small cell lung cancer,leading to an imbalance in the immune microenvironment,and is an important mechanism for causing patients prognostic death,which can be used as a prognostic biomarker for evaluating immune cell infiltration.关键词
非小细胞肺癌/肺特异性X蛋白/免疫细胞浸润/生物标志物Key words
Non-small cell lung cancer/Lung specific X protein/Immune cell infiltration/Biomarkers分类
医药卫生引用本文复制引用
鲁欣然,王宁,刘志强,赵月霞,曹新桥,刘晓佳..LUNX基因作为与免疫细胞浸润相关的非小细胞肺癌预后生物标志物[J].中国免疫学杂志,2024,40(6):1197-1202,6.基金项目
衡水市科技计划项目(2018014002Z). （2018014002Z）
