不孕症合并高催乳素血症的诊治OA北大核心CSTPCD
Diagnosis and treatment of infertility with hy-perprolactinemia
高催乳素血症是一种比较常见的内分泌疾病,在不孕症患者中的发病率高于普通人群.高催乳素血症的诊断需要联合患者血清催乳素水平与临床表现综合判断.催乳素能够通过中枢性、周围性等多种机制对生殖系统产生影响,因此,高催乳素血症不仅影响女性的生育功能,而且也可能增加流产风险.确诊高催乳素血症后,对于有生育需求的患者应积极治疗,推荐使用的药物为多巴胺受体激动剂;但一旦妊娠,则建议绝大多数轻-中度高催乳素血症患者停用多巴胺受体激动剂.
Hyperprolactinemia is a relatively common endocrine disease with a higher incidence in infertility patients than in the general population.The diagnosis of hyperprolactinemia requires a combination of serum prolactin level and clinical manifestations.Prolactin can affect the reproductive system through a variety of mechanisms,such as central and peripheral,so hy-perprolactinemia not only affects the reproductive function of patients,but also may increase the risk of abortion.Patients diagnosed with hyperprolactinemia who have fertility needs should be actively treated,and the drugs recommended are dopamine agonists.Once pregnancy is detected,dopamine agonist discontinu-ation is recommended in the vast majority of patients with mildtomoderate hyperprolactinemia.
蒋术一;王秀霞
中国医科大学附属盛京医院生殖医学中心,辽宁沈阳 110020
基础医学
不孕症高催乳素血症体外受精-胚胎移植复发性流产
infertilityhyperprolactinemiaIVF-ETrecurrent spontaneous abortion
《中国实用妇科与产科杂志》 2024 (006)
583-587 / 5
国家重点研发计划(2023YFC2705402)
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