中国药业2024，Vol.33Issue(12)：93-96,4.DOI:10.3969/j.issn.1006-4931.2024.12.021
温针灸联合复方雪莲胶囊治疗强直性脊柱炎对软骨代谢和炎性反应的影响
Effect of Warm Acupuncture and Moxibustion Combined with Compound Xuelian Capsules on the Cartilage Metabolism and Inflammatory Reaction in the Treatment of Ankylosing Spondylitis
摘要
Abstract
Objective To investigate the effect of warm acupuncture and moxibustion combined with Compound Xuelian Capsules on the cartilage metabolism and inflammatory reaction in the treatment of ankylosing spondylitis.Methods A total of 178 patients with ankylosing spondylitis admitted to the hospital from June 2020 to June 2022 were selected and divided into the control group and the observation group based on different treatment regimens,with 89 cases in each group.The patients in the two groups were treated with warm acupuncture and moxibustion,on this basis,the patients in the observation group were treated with Compound Xuelian Capsules orally.Both groups were treated continuously for two months.Results The total effective rate in the observation group was 95.51%,which was significantly higher than 85.39%in the control group(P<0.05).After treatment,the Bath ankylosing spondylitis disease activity index(BASDAI),Bath ankylosing spondylitis functional index(BASFI)and visual analogue scale(VAS)scores in the two groups significantly decreased;the distances of occipital to wall and finger to ground significantly decreased;the lumbar mobility significantly improved;the expression levels of serum cartilage oligomeric matrix protein(COMP),interleukin-35(IL-35),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-2(IL-2)and interleukin-17(IL-17)significantly decreased(P<0.05).The above indexes in the observation group were significantly better than those in the control group(P<0.05).After treatment,the relief time of lower back pain,joint edema,joint pain,and morning stiffness in the observation group was significantly shorter than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.49%,which was significantly lower than 10.11%in the control group(P<0.05).Conclusion Warm acupuncture and moxibustion combined with Compound Xuelian Capsules can effectively relieve the clinical symptoms of patients with ankylosing spondylitis,alleviate joint pain,inhibit inflammatory reaction,and decrease the expression level of serum inflammatory factors.关键词
强直性脊柱炎/温针灸/复方雪莲胶囊/软骨代谢/炎性反应/临床疗效Key words
ankylosing spondylitis/warm acupuncture and moxibustion/Compound Xuelian Capsules/cartilage metabolism/inflammatory reaction/clinical efficacy分类
医药卫生引用本文复制引用
王喆,何强,何昊..温针灸联合复方雪莲胶囊治疗强直性脊柱炎对软骨代谢和炎性反应的影响[J].中国药业,2024,33(12):93-96,4.基金项目
四川省科技计划项目[2023YFSK473]. （）
