妊娠晚期孕妇血清hs-CRP水平、GBS感染对妊娠及新生儿结局的影响OA

Objective:To analyze the relationship between serum levels of hypersensitive C-reactive protein(hs CRP),infection with Group B streptococci(GBS)in the reproductive tract,and pregnancy and neonatal outcomes in late pregnancy women.Methods:A retrospective analysis was conducted on 90 late pregnancy pregnant women who were diagnosed and treated in our hospital from January 2022 to October 2022.They were divided into groups based on the presence or absence of premature rup-ture of membranes.41 late pregnancy pregnant women who were about to experience premature rupture of membranes were as-signed to the observation group,and 49 late pregnancy pregnant women who did not experience premature rupture of mem-branes were assigned to the control group.Before the occurrence of premature rupture of membranes in late pregnancy,serum hs CRP levels were measured.Two sets of reproductive tract secretions from late pregnancy women were collected for bacterial culture to detect GBS infection and the number of GBS pathogens.Nasopharyngeal swab samples were collected after neonatal delivery to detect the positive rate of GBS.Compare the clinical significance of serum hs CRP levels and GBS infection in pre-dicting premature rupture of membranes between two groups of pregnant women,and compare and analyze the impact of serum hs CRP and GBS infection on the outcomes of pregnant women and newborns with premature rupture of membranes.Result:The positive rates of hs CRP and GBS in the observation group were higher than those in the control group(P<0.05);The levels of Hs-CRP and the number of GBS pathogens in the observation group were higher than those in the control group(P<0.05);The sensitivity and specificity of combining serum hs CRP levels and the number of GBS pathogens in diagnosing pre-mature rupture of membranes are higher than the diagnostic value of a single test;The cesarean section rate and premature birth rate of serum hs CRP positive individuals were higher than those of negative individuals(P<0.05).The cesarean section rate,intrauterine infection rate,premature birth rate,neonatal asphyxia rate,and intrauterine infection rate of GBS positive in-dividuals were higher than those of negative individuals(P<0.05).Conclusion:GBS infection in the reproductive tract of late pregnancy pregnant women can induce premature rupture of membranes,increase the probability of neonatal infection,and have a higher risk of adverse perinatal outcomes.