血清甲胎蛋白、白介素-6与新生儿黄疸严重程度及肝功能的关系研究OA

Objective:To investigate the relationship between serum alpha-fetoprotein(AFP)and interleukin-6(IL-6)and the se-verity of neonatal jaundice and liver function.Methods:125 cases of neonatal jaundice in our hospital from April 2019 to April 2023 were selected as the observation group.According to the severity,they were divided into mild group,moderate group and severe group.40 normal neonates were selected as control group.Serum AFP,IL-6 in observation group and control group,mild group,moderate group and severe group were compared.Pearson correlation was used to analyze the relationship between serum AFP,IL-6 and total bilirubin(TBIL),direct bilirubin(DBIL),indirect bilirubin(IBIL),and liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST)]in neonatal jaundice children.Results:The levels of serum AFP and IL-6 in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Serum AFP and IL-6 levels were significantly different in mild group,moderate group and severe group(P<0.05).With the increase of neonatal jaundice severity,serum AFP and IL-6 levels increased.Serum TBIL,DBIL and IBIL levels were signifi-cantly different in mild,moderate and severe groups(P<0.05).There were significant differences in serum ALT and AST lev-els among mild,moderate and severe groups(P<0.05).According to Pearson correlation analysis,serum AFP and IL-6 levels were positively correlated with the levels of TBIL,DBIL,IBIL,ALT and AST in neonatal jaundice children(P<0.05).Con-clusion:The abnormal expression of AFP and IL-6 in the serum of neonataljaundice children is closely related to the severity of the disease and liver function,which is worthy of clinical intervention in the above aspects.