中国实用妇科与产科杂志2024，Vol.40Issue(6)：661-664,4.DOI:10.19538/j.fk2024060118
子宫内膜癌及子宫内膜不典型增生患者分子分型特征与宫腔镜治疗疗效和临床病理特征关系研究
A study analysing the molecular typing characteristics of patients with endometrial cancer and endometrial atypical hyperplasia in relation to the efficacy of hysteroscopic treatment and clinicopathological features
摘要
Abstract
Objective To investigate the molecular typing characteristics of patients with endometrial cancer(EC)and endometrial atypical hyperplasia(EAH)in relation to the efficacy of hysteroscopic treatment and clinicopathological fea-tures.Methods EC(75 cases)and EAH(81 cases)patients who visited Tangshan Maternal and Child Health Hospital from January 2018 to January 2021 were selected as the research subjects.All patients received hysteroscopic endometri-al lesion resection combined with progesterone treatment.The baseline and pathological data of the two groups of patients were collected,and logistic regression was used to analyse the relationship between the different molecular typing fea-tures,clinicopathological features and treatment effects,and to construct the predictive model for the prognosis of EC and EAH.Results The total effective rate for EC was 85.33％(64/75)and 80.25％(65/81)for EAH.The results of logical re-gression analysis showed that lymph node metastasis(OR=4.265,P=0.003)and clinical stage(OR=2.859,P=0.021)were independent risk factors affecting the therapeutic efficacy of EC patients(P＜0.05),and estrogen receptor(OR=3.582,P=0.013)were independent risk factors affecting the therapeutic efficacy of EAH patients(P＜0.05).Conclusion Lymph node metastasis,clinical stage and estrogen receptor status affects the efficacy of treatment in different molecu-lar typing of EC patients,and estrogen receptor status affects the efficacy of fertility treatment in EAH patients.关键词
子宫内膜癌/子宫内膜不典型增生/分子分型特征/临床病理特征Key words
endometrial cancer/endometrial dysplasia/molecular classification features/clinicopathological features分类
医药卫生引用本文复制引用
李冰,习开超,高丽丽..子宫内膜癌及子宫内膜不典型增生患者分子分型特征与宫腔镜治疗疗效和临床病理特征关系研究[J].中国实用妇科与产科杂志,2024,40(6):661-664,4.基金项目
卫生部医药卫生科技项目(13010520190917) （13010520190917）
