肿瘤防治研究2024，Vol.51Issue(6)：455-461,7.DOI:10.3971/j.issn.1000-8578.2024.23.1342
分子病理风险分级评估WHO1级脑膜瘤生物学行为及患者预后
Molecular Pathological Risk Grade Evaluates Biological Behavior and Prognosis of Patients with WHO Grade 1 Meningiomas
曾令成 1厉华 1陈如东 1杨洪宽 1陈坚 1于加省1
作者信息
- 1. 430030 武汉,华中科技大学同济医学院附属同济医院神经外科
- 折叠
摘要
Abstract
Objective To explore the correlation of molecular pathological grading with WHO grade 1 meningioma recurrence,malignant progression,and patients'survival.Methods The medical records and paraffin-embedded tissues of patients with surgically resected WHO grade 1 meningioma were collected.The molecular pathological risk grading suggested by Maas et al.was adopted,and the patients were graded as low,intermediate,and high risk.Univariate log-rank test and multivariate Cox regression analyses were performed to determine the relationship between molecular risk grading and patient progression-free survival(PFS),malignant progression-free survival(MPFS),and overall survival(OS).Results Among 198 patients,152(76.8%)were graded as low risk,showing no 1p deletion;42(21.2%)patients were graded as intermediate risk,including 18 patients with 1p deletion,10 patients with 1p combined with 6q deletion,and 14 patients with 1p combined with 14q deletion;and 4(2%)patients were graded as high risk,including two patients with TERT promoter mutation,one patient with CDKN2A/B homozygous deletion,and one patient with 1p,6p,and 14q combined deletion.Multivariate analysis showed that molecular risk grading was negatively associated with PFS(HR:0.029,95%CI:0.011-0.080),MPFS(HR:0.032,95%CI:0.004-0.274),and OS(HR:0.074,95%CI:0.032-0.174;P<0.05).Conclusion The biological behavior of histological grade 1 meningiomas still exhibits heterogeneity,and further molecular pathological risk grading can more accurately reflect their biological behavior and evaluate patient prognosis.关键词
脑膜瘤/分子病理/生存Key words
Meningioma/Molecular pathology/Prognosis分类
医药卫生引用本文复制引用
曾令成,厉华,陈如东,杨洪宽,陈坚,于加省..分子病理风险分级评估WHO1级脑膜瘤生物学行为及患者预后[J].肿瘤防治研究,2024,51(6):455-461,7.
