11例SMARCA4(BRG1)缺失性癌的临床病理分析OACSTPCD
Clinicopathological Analysis of 11 Cases of SMARCA4(BRG1)-deficient Carcinoma
目的 探讨SMARCA4(BRG1)缺失性癌患者的临床病理特征、免疫表型及诊治要点.方法 回顾性分析11例SMARCA4(BRG1)缺失性癌患者的临床资料,总结其HE染色后的形态及免疫组织化学特征,并结合文献进行分析.结果 11例患者中男性8例,女性3例;中位年龄60岁.8例行根治性手术切除,3例行传统化疗联合靶向及免疫治疗.镜下肿瘤细胞胞质丰富、红染,呈上皮样、横纹肌样或梭形,具明显的嗜酸性核仁,核分裂象易见(>5/10 HPF),肿瘤组…查看全部>>
Objective To investigate the clinicopathological features,immunophenotype,diagnosis and treatment of SMARCA4(BRG1)-deficient carcinoma.Methods Clinical data of 11 patients with SMAR-CA4(BRG1)-deficient cancer were collected.The morphologic and immunohistochemical features of this tumour were summarized,and the relevant literature was reviewed.Results Among the 11 cases of SMARCA4(BRG1)-deficient carcinoma,eight were male and three were female,with median age…查看全部>>
江晓珍;郭峰棻;盛以芸;梁圣楠;万红萍;邓葵
330006 南昌,南昌大学第一附属医院病理科330006 南昌,南昌大学第一附属医院骨科330006 南昌,南昌大学第一附属医院病理科330006 南昌,南昌大学第一附属医院病理科330006 南昌,南昌大学第一附属医院病理科330006 南昌,南昌大学第一附属医院骨科
基础医学
SMARCA4(BRG1)SWI/SNF复合体免疫表型
SMARCA4(BRG1)SWI/SNF complexImmunophenotype
《肿瘤防治研究》 2024 (6)
469-474,6
Science and Technology Program of Health Commission of Jiangxi Province(No.202310228)Science and Technology Program of Jiangxi Education Department(No.GJJ190119) 江西省卫生健康委科技计划(202310228)江西省教育厅科技计划(GJJ190119)
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