虚拟现实技术对帕金森病患者认知功能和生活质量影响的Meta分析OA北大核心CSTPCD
Effect of virtual reality on cognitive function and quality of life in patients with Parkinson's disease:a meta-analy-sis
目的 评价虚拟现实(VR)技术对帕金森病患者认知功能和生活质量的影响. 方法 计算机检索中国生物医学文献数据库、中国知网、万方数据库、维普数据库、Cochrane Library、Web of Science、Embase和PubMed中关于VR技术干预帕金森病患者的随机对照试验(RCT),检索时限从建库至2024年2月29日.对照组接受常规认知训练、常规平衡训练或常规物理治疗,试验组接受VR技术干预.采用Cochrane协作网的5.1.0版RCT偏倚风险评估工具对纳入文献进行质量评价,采用Revman5.4软件进行数据分析,采用GRADE对结局指标进行证据质量评价. 结果 最终纳入RCT 13篇,涉及患者426例.部分文献未对分配隐藏和盲法进行描述,选择性报告研究结果或其他偏倚不清楚.Meta分析显示,VR技术可以有效改善帕金森病患者蒙特利尔认知评估(MoCA)评分(MD=1.11,95%CI 0.31～1.90,P=0.006)、连线测试(TMT)-A评分(MD=-6.25,95%CI-11.71～-0.78,P=0.030)、抑郁评分(SMD=-0.56,95%CI-0.95～0.18,P=0.004),但对TMT-B评分(MD=-6.01,95%CI-28.16～16.14,P=0.590)、统一帕金森病综合评定量表第二部分(UPDRS-Part II)评分(MD=-2.11,95%CI-4.97～0.75,P=0.150)、帕金森病患者生活质量问卷(PDQ-39)评分(MD=-0.92,95%CI-4.03～2.19,P=0.560)效果不明显.VR技术对MoCA评分、UPDRS-Part II评分和PDQ-39评分的证据等级为低级,TMT评分和抑郁评分为中等. 结论 VR技术可以有效改善帕金森病患者的认知功能和抑郁,但在改善日常生活活动能力和生活质量方面效果不显著.
Objective To evaluate the effect of virtual reality(VR)on cognitive function and quality of life in patients with Parkin-son's disease. Methods A systematic search of CBM,CNKI,Wanfang data,VIP,Cochrane Library,Web of Science,Embase,and PubMed was carried out to identify randomized control trials(RCT)about the effect of VR technology on pa-tients with Parkinson's disease from inception to February 29th,2024.The control group received routine cogni-tive training,balance training or physical therapy,and the experimental group received VR technology.The quali-ty of articles was evaluated using the Cochrane Collaboration's 5.1.0 RCT risk assessment tool for bias.The meta-analysis was performed using Revman5.4.GRADE was used to evaluate the evidence quality of outcome indica-tors. Results A total of 13 literatures involving 426 patients were included.Allocation concealment and blind methods were not described in most literatures,and selective reporting of research results or other biases was unclear.VR tech-nology could improve the Motreal Cognitive Assessment(MoCA)score(MD=1.11,95%CI 0.31 to 1.90,P=0.006),Trail Making Test(TMT)-A score(MD=-6.25,95%CI-11.71 to-0.78,P=0.030)and depression scale score(SMD=-0.56,95%CI-0.95 to 0.18,P=0.004)of patients with Parkinson's disease;however,it did not improve TMT-B score(MD=-6.01,95%CI-28.16 to 16.14,P=0.590),Unified Parkinson's Disease Rat-ing Scale(UPDRS)-Part II score(MD=-2.11,95%CI-4.97 to 0.75,P=0.150)and Parkinson's Disease Ques-tionnaire(PDQ-39)score(MD=-0.92,95%CI-4.03 to 2.19,P=0.560).For quality of evidence,MoCA score,UPDRS-Part II score and PDQ-39 score were low,and depression score and TMT score were moderate. Conclusion VR technology can improve the cognitive function and depression of patients with Parkinson's disease;how-ever,no significant improvement is found in activities of daily living and quality of life.
吕美玲;王洁;曾维斯;温晓婷;楚鑫
成都中医药大学护理学院,四川成都市 610075成都中医药大学附属医院护理部,四川成都市 610072
临床医学
帕金森病虚拟现实认知功能生活质量Meta分析
Parkinson's diseasevirtual realitycognitive functionquality of lifemeta-analysis
《中国康复理论与实践》 2024 (006)
648-656 / 9
成都中医药大学教育教学改革项目重点项目(No.JGJD202356) Supported by Education and Teaching Reform Project of Chengdu University of Traditional Chinese Medicine(No.JGJD202356)
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