定量核磁共振技术在中药质量控制中的应用进展OACSTPCD

Quality control of traditional Chinese medicine(TCM)is the foundation for ensuring the safety,efficacy and quality stability of TCM and the premise for the standardization,modernization,and internationalization of TCM.It is thus of great significance to select an appropriate analysis method in the quality control of TCM.Compared with thin-layer chromatography,gas chromatography,high performance liquid chromatography and other conventional methods,quantitative nuclear magnetic resonance(qNMR)is suitable for the analysis of various components in TCM.This method can be used as a powerful tool for the quality control of TCM due to its convenient sample preparation,short measurement time,no need of reference substances,and integration of qualitative identification and quantitative analysis.This paper introduces qNMR regarding the basic principles,quantitative methods,and applications in Pharmacopoeia and reviews the research progress of qNMR in the quality control of Chinese medicinal materials and the preparations,reference substances,and the production process of TCM.Moreover,this paper points out existing problems and envisions the prospects of qNMR,aiming to provide a theoretical basis and technical support for the application of qNMR in the quality control of TCM.