吉林大学学报（医学版）2024，Vol.50Issue(3)：864-871,8.DOI:10.13481/j.1671-587X.20240334
巨噬细胞极化与口腔疾病关系的研究进展
Research progress in relationship between macrophage polarization and oral diseases
摘要
Abstract
The macrophages,as a crucial component of the body's immune system,can be polarized into M1 and M2 types by different cellular molecules in various environments,and contribute to the progression of various diseases.In inflammatory responses,the M1 macrophages are primarily regarded as the pro-inflammatory cells,facilitate the inflammation progression,tissue destruction,and bone resorption,while M2 macrophages,as inflammatory cells,participate in tissue healing and bone repairment.In the tumor microenvironment,the roles of M1 and M2 macrophages are reversed.The periodontitis,pulpitis,and oral squamous cell carcinoma(OSCC)are the most prevalent inflammation and tumor in the oral cavity.Therefore,this article summarizes the relevant researches from home and abroad on the polarization of macrophages in oral inflammatory responses such as periodontitis,peri-implantitis,and pulpitis,bone remodeling during orthodontic treatment,and OSCC,and elucidate the metabolic activities of macrophages in infiammation,tumor,and bone remodeling and the mechanism of regulating the onset and development of diseases by the macrophage polarization,and provides new perspectives for the clinical treatment.关键词
巨噬细胞极化/炎症/口腔鳞状细胞癌/骨改建/牙周炎Key words
Macrophage polarization/Inflammation/Oral squamous cell carcinoma/Bone remodel/Periodontitis分类
医药卫生引用本文复制引用
于依岩,张志民,陈佳文,刘新,李岩,赵洪岩..巨噬细胞极化与口腔疾病关系的研究进展[J].吉林大学学报（医学版）,2024,50(3):864-871,8.基金项目
吉林省卫健委科技能力提升计划项目(2021TC028) （2021TC028）
