吉林大学学报（医学版）2024，Vol.50Issue(3)：786-790,5.DOI:10.13481/j.1671-587X.20240323
急性缺血性脑卒中患者血清中同型半胱氨酸与炎症反应及氧化应激的关联性分析
Analysis on association between serum homocysteine and inflammatory response and oxidative stress in patients with acute ischemic stroke
摘要
Abstract
Objective:To discuss the correlation between homocysteine(Hcy)and inflammatory responses as well as oxidative stress,and to analyze its role in the occurrence and development of acute ischemic stroke(AIS).Methods:Thirty-eight patients with their first incidence of AIS were selected as AIS group,and according to the principles of case-control study,45 healthy individuals undergwent routine health examination during the same period were selected as control group.The levels of homocysteine and inflammatory cytokine interleukin(IL)-6,and tumor necrosis factor α(TNF-α)in serum of the subjects in two groups were detected by enzyme-linked immunosorbent assay(ELISA)method;the level of highly sensitive C-reactive protein(hs-CRP)of the subjects in two groups was detected by immunoturbidimetry;the levels of malondialdehyde(MDA)and activities of superoxide dismutase(SOD)in serum of the subjects in two groups were detected by chemical colorimetry;Pearson's correlation analysis was used to analyze the correlation between serum Hcy level and levels of inflammatory markers and oxidative stress indicators of the AIS patients.Results:Compared with control group,the levels of Hcy,hs-CRP,TNF-α,IL-6,and MDA in serum of the patients in AIS group were significantly increased(P<0.05),while the activity of SOD was significantly decreased(P<0.05).The level of Hcy in serum of the AIS patients was positively correlated with the levels of hs-CRP,TNF-α,IL-6,and MDA(r=0.615,P<0.05;r=0.632,P<0.05;r=0.598,P<0.05;r=0.612,P<0.05),and negatively correlated with the activity of SOD(r=-0.325,P<0.05).Conclusion:The Hcy level in serum of the AIS patients is closely associated with the inflammatory factors and oxidative damage.Hcy can promote the production of oxidative free radicals and inflammatory factors and cause damage to the endothelial cells and play a significant clinical role in the occurrence and development of AIS.关键词
急性缺血性脑卒中/同型半胱氨酸/炎症因子/氧化应激/白细胞介素6Key words
Acute ischemic stroke/Homocysteine/Inflammatory cytokines/Oxidative stress/Interleukin-6分类
医药卫生引用本文复制引用
唐晶,李环,张硕,姜立刚..急性缺血性脑卒中患者血清中同型半胱氨酸与炎症反应及氧化应激的关联性分析[J].吉林大学学报（医学版）,2024,50(3):786-790,5.基金项目
吉林省中医药管理局重点研究室项目(2022-Z70) （2022-Z70）
吉林省吉林市科技局科技创新发展计划项目医疗卫生指导性专项(20230406105) （20230406105）
