中国耳鼻咽喉头颈外科2024，Vol.31Issue(6)：360-363,4.DOI:10.16066/j.1672-7002.2024.06.005
糖皮质激素治疗急性低频感音神经性聋疗效的对比分析
A comparative study on efficacy of glucocorticoids in patients suffering acute low-tone sensorineural hearing loss
摘要
Abstract
OBJECTIVE To investigate the therapeutic role of glucocorticoids in acute low-tone sensorineural hearing loss and to guide clinical management.METHODS Recorded electrocochleograms in 200 ears.Based on the results,these patients were divided into-SP/AP≥0.4 with 110 ears and-SP/AP<0.4 with 90 ears.In a randomized,single-blind fashion,the two groups were divided into systemic,local,and non-glucocorticoid-treated groups separately.We compared treatment effects between different groups.RESULTS The-SP/AP ratios are abnormally increased in 55%of ALHL patients.In patients with-SP/AP≥0.4,the effective treatment rates of systemic,local and non-glucocorticoid groups were 92.50%,94.59%and 72.73%,respectively.A comparison between systemic and local glucocorticoid delivery regimes,P>0.05,and the two groups were compared with the non-glucocorticoid group,P≤0.05.In patients with-SP/AP<0.4,compared the efficacy of the three groups,P>0.05.CONCLUSION In patients with-SP/AP≥0.4,glucocorticoids are more effective than non-glucocorticoid,systemic glucocorticoids are as effective as local glucocorticoids.In patients with-SP/AP<0.4,In contrast,systemic,local and non glucocorticoids are equally effective.关键词
耳聋/听觉丧失,感音神经性/糖皮质激素类/急性低频感音神经性聋/耳蜗电图Key words
Deafness/Hearing Loss,Sensorineural/Glucocorticoids/acute low-tone sensorineural hearing loss/electrocochleograms引用本文复制引用
张呈辉..糖皮质激素治疗急性低频感音神经性聋疗效的对比分析[J].中国耳鼻咽喉头颈外科,2024,31(6):360-363,4.基金项目
河南省科技攻关项目(232102310164) （232102310164）
