康复学报2024，Vol.34Issue(3)：225-232,8.DOI:10.3724/SP.J.1329.2024.03004
基于功能近红外光谱探讨上肢获益对扩现象的神经行为学机制
Neurobehavioral Mechanism of Cross-Education Phenomenon in the Upper Limb Based on Functional Near-Infrared Spectroscopy
摘要
Abstract
Objective To explore the neurobehavioral mechanism of cross-education phenomenon and asymmetry in the up-per limb based on functional near-infrared spectroscopy(fNIRS).Methods A total of 17 healthy subjects recruited by Sir Run Run Hospital of Nanjing Medical University from November 2023 to January 2024 were selected in a randomized cross-over trial.Pur-due pegboard training with the contralateral upper limb of unilateral limb was taken as the contralateral training,and the number of Purdue pegboard plug-ins completed within a limited time as the task performance.fNIRS was used to collect the cerebral hemody-namic changes of healthy right-handed individuals after contralateral training when the left and right hand performed operational ac-tivities and record the behavioral data,and compare the cerebral cortex activation and behavioral performance of the left and right hands before and after contralateral training.Results After contralateral training,the performance of the left hand was significantly better than that before training(t=-8.865,P<0.010),while the performance of the right hand did not change after training(t=-1.689,P=0.606).In addition,the left pre-motor and supplementary motor area(CH 29),right pre-motor and supplementary motor area(CH 16,CH 17)and right primary motor cortex(CH 09)were more significantly activated after contralateral training when subjects per-formed the Purdue pegboard task with left hand(P<0.05).However,the right pre-motor and supplementary motor area(CH 19),right primary somatosensory cortex(CH 08)and right primary motor cortex(CH 10)showed a decreasing trend in the activation after contralateral training when subjects performed the Purdue pegboard task with right hand(P<0.05).Conclusion Cross-educa-tion of the upper limbs is asymmetrical,indicating that the non-dominant hand experiences greater benefits compared to the domi-nant hand.Cross-education may be attributed to enhance the cortical activation of the bilateral pre-motor and supplementary motor area(pSMA)to improve the task performance of the non-training limb.关键词
脑卒中/获益对扩/运动技能/上肢功能/功能近红外光谱Key words
stroke/cross education/motor skill/upper limb function/functional near-infrared spectroscopy引用本文复制引用
潘颖颖,王梦寰,王乙休,谢敏,江钟立,林枫..基于功能近红外光谱探讨上肢获益对扩现象的神经行为学机制[J].康复学报,2024,34(3):225-232,8.基金项目
国家重点研发计划项目(2022YFC2009700) （2022YFC2009700）
国家自然科学基金项目(81672255) （81672255）
江苏省重点研发计划重点项目(BE2023023-4) （BE2023023-4）
