吉林医药学院学报2024，Vol.45Issue(4)：269-272,4.
高甘油三酯血症对急性心梗PCI后缺血-再灌注损伤的影响
Effect of Hypertriglyceridemia on Ischemia-Reperfusion Injury after Acute Myocardial Infarction PCI
摘要
Abstract
Objective To investigate the effect of hypertriglyceridemia on ischemia-reperfusion injury during percutaneous coronary inter-vention(PCI)in acute myocardial infarction(AMI).Methods A retrospective analysis was conducted on 132 patients with AMI who un-derwent emergency PCI from October 2021 to December 2022.Among them,47 patients with hypertriglyceridemia were included in the hypertriglyceridemia group,and 85 patients with normal triglycerides were included in the control group.Detect and record general clini-cal data of patients,including creatine kinase(CK),creatine kinase isoenzyme CK-MB,cardiac troponin T(cTnT),N-terminal proBNP precursor(NT proBNP),echocardiography,oxidative stress indicators including superoxide dismutase(SOD)and malondialdehyde(MDA),Inflammatory indicator interleukin-6(IL-6)levels.Results Compared with the control group,the BMI and triglyceride levels in patients with hypertriglyceridemia were significantly increased(P<0.05),and there was no statistically significant difference in other indicators;The levels of CK and CK-MB significantly increased(P<0.05),while the difference in cTnT was not significant;LVEF signifi-cantly decreased(P<0.05),NT proBNP significantly increased(P<0.05),and LVEDD difference was not significant;SOD significantly decreased,MDA and IL-6 levels significantly increased(P<0.05).Conclusion Hypertriglyceridemia can significantly exacerbate ischemia-reperfusion injury after acute myocardial infarction PCI,and timely correction of triglyceride imbalance is of great significance for improving clinical outcomes after PCI.关键词
高甘油三酯血症/急性心肌梗死/经皮冠状动脉介入术/缺血再灌注损伤Key words
hypertriglyceridemia/acute myocardial infarction/percutaneous coronary intervention/ischemia reperfusion injury分类
医药卫生引用本文复制引用
杨敏,钱红波,桂莹晶,张大发,傅聪..高甘油三酯血症对急性心梗PCI后缺血-再灌注损伤的影响[J].吉林医药学院学报,2024,45(4):269-272,4.基金项目
皖南医学院中青年科研基金(WK2018F07) （WK2018F07）
安徽省教育厅高校科研计划项目(2022AH030122) （2022AH030122）
