右美托咪定在胸腔镜肺癌根治术中的应用价值OACSTPCD

Objective:To study the application value of dexmedetomidine in thoracoscopic radical resection of lung cancer.Methods:From Jan.2020 to Sep.2022,80 lung cancer patients who underwent thoracoscopic radical resection were selected.According to random number table,patients were assigned to study group(n=40)and control group(n=40).The study group was treated with the lung protective ventilation strategy and dexmedetomidine;the control group was treated with the lung protective ventilation strategy.Group comparison was performed in the operation time,infusion volume,single lung ventilation time,blood loss,heart rate,mean arterial pressure(MAP),interleukin-6,transforming growth factor-β1,tumor necrosis factor-α,T lymphocyte subsets,pulmonary function,oxida-tive stress indicators,and pulmonary complications.Results:There were no significant differences between the two groups in operation time,infusion volume,one lung ventilation duration and bleeding volume(P＞0.05).At the two-side lung ventilation and the completion of surgery,heart rate and MAP between the two groups were not significantly different(P＞0.05);at 30 min and 90 min of one lung ventilation,heart rate and MAP in the study group were lower than those in the control group(P＜0.05).Before surgery and during the two-side lung ventilation,the inflammatory factors between two groups were not significantly different(P＞0.05);at30 min and90 min of one lung ventilation and the completion of surgery,interleukin-6,transforming growth factor-β1 and tumor necrosis factor-α in the study group were lower than those in the control group(P＜0.05);the incidence of pulmonary complications in the study group was low-er than that in the control group(7.50%vs.27.50%,P＜0.05).Before surgery,there were no significant differences in T lymphocyte subsets,lung function,and oxidative stress indicators between the two groups(P＞0.05);after surgery,malondialdehyde in the study group was lower than the control group;the other indicators were higher than the control group(P＜0.05).Conclusions:During the tho-racoscopic radical treatment of lung cancer,the application of the lung protective ventilation strategy and dexmedetomidine can avoid the high fluctuations of hemodynamic indicators and reduce the inflammatory reaction,oxidative stress response and pulmonary complica-tions,increase the surgical safety and promote the improvement of lung function.