腹腔镜外科杂志2024，Vol.29Issue(5)：326-331,6.DOI:10.13499/j.cnki.fqjwkzz.2024.05.326
右美托咪定在胸腔镜肺癌根治术中的应用价值
The application value of dexmedetomidine in thoracoscopic radical surgery for lung cancer
摘要
Abstract
Objective:To study the application value of dexmedetomidine in thoracoscopic radical resection of lung cancer.Methods:From Jan.2020 to Sep.2022,80 lung cancer patients who underwent thoracoscopic radical resection were selected.According to random number table,patients were assigned to study group(n=40)and control group(n=40).The study group was treated with the lung protective ventilation strategy and dexmedetomidine;the control group was treated with the lung protective ventilation strategy.Group comparison was performed in the operation time,infusion volume,single lung ventilation time,blood loss,heart rate,mean arterial pressure(MAP),interleukin-6,transforming growth factor-β1,tumor necrosis factor-α,T lymphocyte subsets,pulmonary function,oxida-tive stress indicators,and pulmonary complications.Results:There were no significant differences between the two groups in operation time,infusion volume,one lung ventilation duration and bleeding volume(P＞0.05).At the two-side lung ventilation and the completion of surgery,heart rate and MAP between the two groups were not significantly different(P＞0.05);at 30 min and 90 min of one lung ventilation,heart rate and MAP in the study group were lower than those in the control group(P＜0.05).Before surgery and during the two-side lung ventilation,the inflammatory factors between two groups were not significantly different(P＞0.05);at30 min and90 min of one lung ventilation and the completion of surgery,interleukin-6,transforming growth factor-β1 and tumor necrosis factor-α in the study group were lower than those in the control group(P＜0.05);the incidence of pulmonary complications in the study group was low-er than that in the control group(7.50%vs.27.50%,P＜0.05).Before surgery,there were no significant differences in T lymphocyte subsets,lung function,and oxidative stress indicators between the two groups(P＞0.05);after surgery,malondialdehyde in the study group was lower than the control group;the other indicators were higher than the control group(P＜0.05).Conclusions:During the tho-racoscopic radical treatment of lung cancer,the application of the lung protective ventilation strategy and dexmedetomidine can avoid the high fluctuations of hemodynamic indicators and reduce the inflammatory reaction,oxidative stress response and pulmonary complica-tions,increase the surgical safety and promote the improvement of lung function.关键词
肺肿瘤/肺癌根治术/胸腔镜检查/右美托咪定/肺保护性通气策略Key words
Lung neoplasms/Radical resection of lung cancer/Thoracoscopy/Dexmedetomidine/Lung protective ventilation strategies分类
医药卫生引用本文复制引用
汪辉,陈刚,王萍,赵仕浩,吴刚,汪方清..右美托咪定在胸腔镜肺癌根治术中的应用价值[J].腹腔镜外科杂志,2024,29(5):326-331,6.基金项目
安徽省科技厅重点研发项目(202104j07020003) （202104j07020003）
