赣南医学院学报2024，Vol.44Issue(6)：549-555,7.DOI:10.3969/j.issn.1001-5779.2024.06.001
LncRNAs在肺癌中的调控作用
The regulatory role of LncRNAs in lung cancer
摘要
Abstract
Lung cancer is one of the common life-threatening tumors.The continuous invasion of lung cancer cells and the interaction in the tumor microenvironment enhance its malignancy.In the process of clinical treatment,lung cancer cells have shown obvious tolerance to chemotherapy and radiotherapy.Long non-coding RNAs(LncRNAs)are a class of RNAs that do not encode proteins,their abnormal expression is related to tumor,especially the progression of lung cancer.This article mainly reviews the LncRNAs related to the proliferation and metastasis,angiogenesis,immune escape,radio-and chemo-therapy resistance of lung cancer.Literature review results show that the proliferation,metastasis,immune escape and treatment resistance of lung cancer are all regulated by LncRNAs,and the overexpression of cancer-promoting LncRNAs contributes to immune escape of lung cancer cells.LncRNAs affect the prognosis of lung cancer patients by affecting the sensitivity of lung cancer cells to chemotherapy such as cisplatin,gefitinib and ocitinib.关键词
肺癌/长链非编码RNA/免疫逃逸/耐药Key words
Lung cancer/Long non-coding RNAs/Immune escape/Resistance分类
医药卫生引用本文复制引用
焦林惠,刘鑫龙,程齐来..LncRNAs在肺癌中的调控作用[J].赣南医学院学报,2024,44(6):549-555,7.基金项目
国家自然科学基金资助项目(82260789) （82260789）
江西省科技厅自然科学基金面上项目(20202BAB206080) （20202BAB206080）
赣州市科技局科技创新计划-创新领军人才项目(202101094460) （202101094460）
