miR-424靶向FBXW7对多发性骨髓瘤细胞增殖、凋亡的影响OACSTPCD
Effect of miR-424 on Proliferation and Apoptosis of Multiple Myeloma Cells by Targeting FBXW7
目的 探讨miR-424 靶向F-box和WD重复结构域 7(F-Box and WD repeat domain containing 7,FBXW7)轴对多发性骨髓瘤(multiple myeloma,MM)细胞增殖、凋亡的影响.方法 以实时荧光定量PCR(RT-qPCR)实验检测人正常骨髓浆细胞与 MM 细胞系 MM.1S、RPMI 8226、U266 中 miR-424 及FBXW7 表达.体外培养U266 细胞并随机分为对照组、miR-…查看全部>>
Objective To investigate the effect of miR-424 on the proliferation and apoptosis of multiple myeloma(MM)cells by targeting the F-box and WD repeat domain containing 7(FBXW7).Methods Real-time fluorescence quantitative PCR(RT-qPCR)experiment was ap-plied to detect the expression levels of miR-424 and FBXW7 in human normal bone marrow plasma cells and MM cell lines MM.1S,RPMI 8226,U266.U266 cells were cultured in vitro and random-ly separated into 5 groups:co…查看全部>>
段晓娟;席振芳;侯瑞红
临汾市人民医院血液内科 山西省临汾市,041000临汾市人民医院血液内科 山西省临汾市,041000临汾市人民医院血液内科 山西省临汾市,041000
临床医学
miR-424FBXW7多发性骨髓瘤增殖凋亡
miR-424FBXW7multiple myelomaproliferationapoptosis
《医学分子生物学杂志》 2024 (4)
334-340,7
临汾市人民医院院级科研基金项目(No.T2023023) This work was supported by a grant from the Linfen City People's Hospital Research Fund Project(No.T2023023)
评论