国际口腔医学杂志2024，Vol.51Issue(4)：467-474,8.DOI:10.7518/gjkq.2024064
牙源性间充质干细胞外泌体在牙髓再生中的作用机制
Effects and mechanism of exosomes derived from dental mesenchymal stem cells on dental pulp regeneration
摘要
Abstract
Pulp regeneration is a new strategy for pulp necrosis treatment based on tissue engineering.Seed cells com-bined with scaffolds and growth factors are used to regenerate dentin,blood vessels,and nerves.As extracellular vesicles with a diameter of approximately 30～150 nm,exosomes play an important role in the transmission of regulatory informa-tion between cells.In recent years,exosomes derived from dental mesenchymal stem cells have attracted attention be-cause of their great potential in pulp regeneration.In this article,the species and culture environment of exosomes derived from dental mesenchymal stem cells were introduced.The effect and mechanism of exosomes derived from dental mesen-chymal stem cells in regulating odontogenic differentiation,angiogenesis,nerve regeneration,and osteoblastic differentia-tion were also reviewed.关键词
外泌体/牙髓再生/牙源性间充质干细胞Key words
exosome/pulp regeneration/dental mesenchymal stem cells分类
医药卫生引用本文复制引用
陆慧,郑烨新,赵玮..牙源性间充质干细胞外泌体在牙髓再生中的作用机制[J].国际口腔医学杂志,2024,51(4):467-474,8.基金项目
Natural Science Foundation of Guangdong Province(2023A1515012554) 广东省自然科学基金(2023A1515012554) （2023A1515012554）
