牙源性间充质干细胞外泌体在牙髓再生中的作用机制OA北大核心CSTPCD

Pulp regeneration is a new strategy for pulp necrosis treatment based on tissue engineering.Seed cells com-bined with scaffolds and growth factors are used to regenerate dentin,blood vessels,and nerves.As extracellular vesicles with a diameter of approximately 30～150 nm,exosomes play an important role in the transmission of regulatory informa-tion between cells.In recent years,exosomes derived from dental mesenchymal stem cells have attracted attention be-cause of their great potential in pulp regeneration.In this article,the species and culture environment of exosomes derived from dental mesenchymal stem cells were introduced.The effect and mechanism of exosomes derived from dental mesen-chymal stem cells in regulating odontogenic differentiation,angiogenesis,nerve regeneration,and osteoblastic differentia-tion were also reviewed.