国际老年医学杂志2024，Vol.45Issue(4)：427-431,5.DOI:10.3969/j.issn.1674-7593.2024.04.008
联苯双酯衍生物对糖尿病肾病和肾功能的影响
Effect of Bifendate Derivatives on Diabetic Nephropathy and Renal Function
摘要
Abstract
Objective To explore the mechanism of bifendate derivatives in improving diabetic nephropathy and renal func-tion.Methods Fifty SPF grade 6-8 week old C57BL/6J mice,of which,15 were in the control group and 35 in the diabetic ne-phropathy model group.The mice in the control group were divided into a normal control group(n=7)and a control administration group(n=8),and the mice in the diabetic nephropathy model group were divided into model group,low-dose administration group,medium-dose administration group,high-dose administration group,and resveratrol-positive drug group(each had 7 mice).Samples were taken after 8 weeks of drug administration.The basic parameters and renal function related indexes of mice were detected,glyco-gen staining experiments detected the accumulation of glycogen in renal tissues,Sirius red staining detected the fibrosis of renal tissues,and proteomic analysis was performed by Q-Exactive mass spectrometer.The differences of the indexes between the comparison groups were analyzed.Results Different doses of bifendate derivatives significantly reduced fasting blood glucose in mice(P<0.05).Medi-um and high doses of bifendate derivatives significantly reduced serum urea nitrogen and creatinine levels in mice(P<0.05).Glyco-gen staining experiments suggested that different doses of benzene bilipid derivatives could alleviate the accumulation of glycogen in the kidneys of mice.Sirius red staining experiments showed that different doses of benzene bisabolol derivatives could alleviate the fibrotic lesions in the kidneys of mice.A total of 5032 proteins were identified by proteomic analysis,and 104 differentially expressed proteins were screened.Conclusion Bifendate derivatives have the potential to be potential drugs for the treatment of diabetes mellitus and re-lated complications such as diabetic nephropathy.关键词
联苯双酯衍生物/糖尿病肾病/肾脏纤维化/差异表达蛋白Key words
Bifendate derivatives/Diabetic nephropathy/Renal fibrosis/Differentially expressed proteins引用本文复制引用
柳月娟,李旗,田福玲,高玲焕,赵铭佳..联苯双酯衍生物对糖尿病肾病和肾功能的影响[J].国际老年医学杂志,2024,45(4):427-431,5.基金项目
河北省自然科学基金(H2019209565) （H2019209565）
河北省中医药管理局科研计划项目(2018175) （2018175）
