国际老年医学杂志2024，Vol.45Issue(4)：490-494,5.DOI:10.3969/j.issn.1674-7593.2024.04.020
NLRP3炎症小体参与糖尿病肾病肾间质纤维化机制的研究进展
Elucidating the Role of the NLRP3 Inflammasome in Renal Interstitial Fibrosis Development within Diabetic Nephropathy Contexts
摘要
Abstract
Renal interstitial fibrosis(RIF)is a crucial and irreversible element that speeds up the advancement of diabetic nephropathy(DN)to end-stage renal disease.DN-RIF,which is mostly caused by long-lasting inflammation,is greatly affected by the NOD-like receptor thermal protein domainassociated protein 3(NLRP3)inflammasome.This inflammasome plays a crucial role in trig-gering inflammatory reactions.The inflammasome has a significant impact in worsening DN-RIF by triggering processes related to in-flammation,oxidative stress,and autophagy.This paper thoroughly analyzes the role of the NLRP3 inflammasome in the development of RIF and explores the possibility of traditional Chinese medicine in specifically targeting this inflammasome to reduce the severity of RIF.The primary objective is to promote progress in treatment approaches for the management of recurrent RIF.关键词
NOD样受体热蛋白结构域相关蛋白3/糖尿病肾病/肾间质纤维化/炎症Key words
NOD-like receptor thermal protein domain associated protein 3/Diabetic nephropathy/Renal interstitial fibro-sis/Inflammatory引用本文复制引用
乔琳,金艳,郭兆安..NLRP3炎症小体参与糖尿病肾病肾间质纤维化机制的研究进展[J].国际老年医学杂志,2024,45(4):490-494,5.基金项目
山东省自然科学基金创新发展联合基金(ZR2022LZY005) （ZR2022LZY005）
