广西医科大学学报2024，Vol.41Issue(5)：716-721,6.DOI:10.16190/j.cnki.45-1211/r.2024.05.011
NFATc4在舌鳞状细胞癌神经侵犯诊断中的作用
The role of NFATc4 in the diagnosis of perineural invasion in tongue squamous cell carcinoma
摘要
Abstract
Objective:To explore the role of activated T-cell nuclear factor cytoplasmic 4(NFATc4)in the diag-nosis of perineural invasion(PNI)in tongue squamous cell carcinoma(TSCC)by comparing the immunohisto-chemical staining characteristics of NFATc4 with those of S100 calcium binding protein(S100)and p75 neuro-trophin receptor(p75)for PNI in TSCC.Methods:A total of 59 pathological specimens of TSCC and 10 precan-cerous lesions were collected as control group.Each specimen underwent serial sectioning and immunohisto-chemical staining to observe the staining of TSCC as well as nerves by NFATc4.These staining patterns were then compared with those of S100 and p75.Results:In the 59 TSCC pathological specimens,the positivity rate of NFATc4 was 47.5%(28/59),and the PNI incidence was 35.6%(21/59).The PNI incidence was higher in the NFATc4 positive expression group than that in the NFATc4 negative expression group(P＜0.05).NFATc4 stain-ing was observed as light staining of the nerve endothelium and staining of the TSCC cell cytoplasm.The identifi-cation results of NFATc4 of nerves were not statistically different from those of S100 and p75(P＞0.05).Conclu-sion:There is an association between NFATc4 expression and the occurrence of PNI.NFATc4 can stain the TSCC tissues while staining the nerve bundles,which makes it possible to visualize the relationship between the tumor and the nerves in the same field of view.This visualization enhances the diagnostic accuracy of PNI,indicating that NFATc4 can potentially serve as a diagnostic indicator for PNI.关键词
活化T细胞核因子胞质4/舌鳞状细胞癌/神经侵犯Key words
activated T-cell nuclear factor cytoplasmic 4/tongue squamous cell carcinoma/perineural invasion分类
医药卫生引用本文复制引用
罗霖,陈昕煜,刘能铭,周博森,陈鹏宁,陈冠希,于大海..NFATc4在舌鳞状细胞癌神经侵犯诊断中的作用[J].广西医科大学学报,2024,41(5):716-721,6.基金项目
广西自然科学基金资助项目(No.2016GXNSFDA380002) （No.2016GXNSFDA380002）
