广西医学2024，Vol.46Issue(4)：514-518,5.DOI:10.11675/j.issn.0253-4304.2024.04.09
不孕症女性患者的生殖道解脲支原体感染情况及其与性功能障碍、阴道微生态及卵巢颗粒细胞MAPK信号通路的关系
Status of Ureaplasma urealyticum infection in genital tract of female patients with infertility and its relation with sexual dysfunction,vaginal microecosystem and ovarian granular cells MAPK signaling pathway
摘要
Abstract
Objective To analyze the status of Ureaplasma urealyticum infection in genital tract of female patients with infertility,and to explore its relation with sexual dysfunction,vaginal microecosystem and ovarian granular cells mitogen activated protein kinase(MAPK)signaling pathway.Methods A total of 85 female patients with infertility,and 80 healthy females after artificial abortion operation were selected as study group or control group,respectively.The status of Ureaplasma urealyticum infection was compared between the two groups.Patients with infertility were assigned to infection group(n=54)or non-infection group(n=31)according to the status of Ureaplasma urealyticum infection.The incidence rate of sexual dysfunction,Female Sexual Function Index(FSFI)scale score,vaginal microecosystem status,and mRNA expression of MAPK signaling pathway key factors in ovarian granular cells were compared between patients of the two groups.Results The infection rate of Ureaplasma urealyticum was higher in the study group than in the control group(63.53％and 1.25％,respectively,P＜0.05).Compared with the non-infection group,the infection group yielded a higher incidence rate of sexual dysfunction,and lower scores of dimensions in terms of sexual desire,sexual arousal,vaginal lubrication,orgasm,and dyspareunia,and a lower total score of FSFI scale,as well as higher abnormal rate of vaginal flora density,abnormal rate of vaginal pH value,and vaginal microecological dysregulation rate,and elevated mRNA expressions of c-Jun N-terminal kinase,p38,extracellular regulated protein kinase in ovarian granular cells(P＜0.05).Conclusion Ureaplasma urealyticum infection in the genital tract of infertility patients is still severe.Ureaplasma urealyticum infection in the genital tract can cause infertility patients with sexual dysfunction,increase vaginal microecological imbalance,and lead to MAPK signaling pathway over-activation in ovarian granular cells to a certain extent.关键词
不孕症/解脲支原体感染/生殖道/性功能/阴道微生态/丝裂原活化蛋白激酶信号通路Key words
Infertility/Ureaplasma urealyticum infection/Genital tract/Sexual function/Vaginal microecology/Mitogen activated protein kinase signaling pathway分类
医药卫生引用本文复制引用
苏芳,江梦华,李玲..不孕症女性患者的生殖道解脲支原体感染情况及其与性功能障碍、阴道微生态及卵巢颗粒细胞MAPK信号通路的关系[J].广西医学,2024,46(4):514-518,5.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220353) （Z-A20220353）
