中国实用神经疾病杂志2024，Vol.27Issue(7)：869-873,5.DOI:10.12083/SYSJ.230942
不同剂量盐酸替罗非班治疗急性非心源性脑梗死患者的疗效及对凝血功能的影响
Effect of different doses of tirofiban hydrochloride in the treatment of patients with acute non-cardiogenic cerebral infarction and its influence on coagulation function
摘要
Abstract
Objective To analyze the therapeutic effect of different doses of tirofiban hydrochloride in the treatment of patients with acute non-cardiogenic cerebral infarction and its influence on coagulation function.Methods Totally 240 patients with acute non-cardiogenic cerebral infarction in Hebei Yanda Hospital from April 2021 to April 2022 were taken as the research objects,and were randomly divided into control group,observation group Ⅰ,observation group Ⅱ,and observation group Ⅲ by computer generated random number sequence,with 60 cases in each group.The control group was treated with conventional symptomatic treatment.Observation group Ⅰ,observation group Ⅱ and observation group Ⅲ were given respective 0.06 μ g/(kg·min),0.08 μg/(kg·min)and 0.1 μg/(kg·min)tirofiban hydrochloride on the basis of the control group.Blood routine indicators(platelet count(PC),platelet aggregation rate,mean platelet volume(MPV),lymphocyte(LYM)and mean platelet volume/lymphocyte(MPVLR))and four coagulation indicators(prothrombin time(PT),fibrinogen(FIB),thrombin time(TT),activated partial thromboplastin time(APTT))in the four groups were compared,and National Institutes of Health stroke scale(NIHSS),modified Rankin scale(mRS)scores of the four groups were analyzed.Results After 3 months of treatment,the PC,platelet aggregation rate and LYM of observation group Ⅲ were lower than those of the control group,observation group Ⅰ and observation group Ⅱ(P<0.05).The MPV and MPVLR of observation group Ⅲ were lower than those of the control group,observation group Ⅰ and observation group Ⅱ(P<0.05).The PT,TT and APTT of observation group Ⅲ were higher than those of the control group,observation group Ⅰ and observation group Ⅱ(P<0.05).The FIB,NIHSS and mRS scores of observation group Ⅲ were lower than those of the control group,observation group Ⅰ and observation group Ⅱ(P<0.05).Conclusion 0.10 μg/(kg·min)tirofiban hydrochloride has a good effect in the treatment of patients with acute non-cardiogenic cerebral infarction.It has a strong anticoagulant effect,and is conducive to inhibiting and preventing thrombosis.关键词
急性非心源性脑梗死/盐酸替罗非班/不同剂量/神经功能缺损/凝血功能Key words
Acute non-cardiogenic cerebral infarction/Tirofiban hydrochloride/Different doses/Neurological deficit/Coagulation function分类
医药卫生引用本文复制引用
杨春景,李敏,代慈祥,陈绘颖,王中魁..不同剂量盐酸替罗非班治疗急性非心源性脑梗死患者的疗效及对凝血功能的影响[J].中国实用神经疾病杂志,2024,27(7):869-873,5.基金项目
2021年廊坊市科学技术研究与发展计划项目(编号:2021013052) （编号:2021013052）
2021年度河北省医学科学研究课题计划项目(编号:20210061) （编号:20210061）
