基于小肠细菌过度增殖的肠道微生物失调与帕金森病的相关性OACSTPCD

There is growing evidence that microbiota and the brain are closely linked through the gut-brain axis.Parkinson's disease(PD)is a common neurodegenerative protein disorder for which no disease interventions are available.Gut microbiota dysbiosis and its metabolites may play a role in the onset and progression of PD,so it is also a potential way to treat PD.Small intestinal bacterial overgrowth(SIBO)has a high prevalence in PD and may be associated with gastrointestinal symptoms(e.g.bloating,belching,abdominal pain,etc.)and fluctuations in motor symptoms.Considering the potential mechanisms of SIBO on PD onset,progression,eradication of SIBO,and other modulation/manipulation of the small intestinal microbiota may slow down PD progression.Therefore,this review focuses on the progress of research on gut microbiota dysbiosis and its metabolites and PD,which is the application of SIBO in PD,to further understand the link between the two,delay or stop the onset and progression of PD,and provide new ideas for treatment.