河南中医2024，Vol.44Issue(6)：968-972,5.DOI:10.16367/j.issn.1003-5028.2024.06.0178
慢性阻塞性肺疾病合并肌肉衰减综合征病机新识
New Insights into the Pathogenesis of Chronic Obstructive Pulmonary Disease Complicated with Muscle Atrophy Syndrome
摘要
Abstract
The pathogenesis of chronic obstructive pulmonary disease(COPD)with muscle atrophy syndrome in TCM is considered to be due to lung-spleen qi deficiency,and it can be treated with methods of reinforcing the lung and spleen and banking up earth to bene-fit metal,etc.Current research has found that its pathogenesis is related to abnormal protein metabolic pathways,inflammation,abnormal endocrine factors,abnormal mitochondrial function,calcium homeosta imbalance,activation and dysfunction of satellite cells,etc.The re-inforcing the lung and spleen method may work by improving abnormal protein metabolism in skeletal muscle,abnormal mitochondrial function in skeletal muscle,calcium homeosta imbalance in skeletal muscle,activation of satellite cells in muscle,and malnutrition.However,there are still some limitations in the current research,such as the material basis and mutual influence mechanism of spleen-lung qi deficiency are still unclear;the research is mostly focused on the effectiveness of formulas,with few reports on the safety of long-term use;and the experimental studies are mostly conducted on animals,with fewer in vitro studies.In the future,it is necessary to strengthen the research on the material basis and mutual influence mechanism of the lung and spleen,and follow up the drug safety of long-term treatment.By studying the effects of TCM on COPD cells cultured in vitro,it is needed to prove that TCM can exert its effects on the cells within the COPD,and explain the mechanism of its treatment from the cellular level.关键词
慢性阻塞性肺疾病/肌肉衰减综合征/肺脾气虚Key words
chronic obstructive pulmonary disease(COPD)/muscle atrophy syndrome/lung-spleen qi deficiency分类
医药卫生引用本文复制引用
刘宇,白丽,樊康康,陈颖,张文静,落超..慢性阻塞性肺疾病合并肌肉衰减综合征病机新识[J].河南中医,2024,44(6):968-972,5.基金项目
山西省中医药管理局中医药科研项目(2020ZYYZ025) （2020ZYYZ025）
山西中医药大学重点学科建设项目(1006Z3) （1006Z3）
