河南中医2024，Vol.44Issue(7)：1121-1127,7.DOI:10.16367/j.issn.1003-5028.2024.07.0206
氧化应激与不孕症研究进展
Research Progress on Oxidative Stress and Infertility
摘要
Abstract
In physiological conditions,the small amount of reactive oxygen species produced by the body plays an important role in fe-male reproductive processes(such as the development and maturation of follicles,ovulation,the activity of the corpus luteum,and em-bryo implantation,etc.)through different signal transduction pathways.In pathological conditions,excessive reactive oxygen species can trigger oxidative stress,leading to metabolic dysfunction,mitochondrial dysfunction,inflammatory responses,and ultimately,the onset of disease.There is a certain correlation between oxidative stress and various reproductive endocrine disorders such as luteal phase defect,endometriosis,and unexplained infertility.Both Western medicine and TCM can achieve satisfactory therapeutic effects by using antioxi-dant therapy to treat infertility.Currently,although the use of antioxidants can effectively alleviate oxidative stress,there is still no com-prehensive understanding of its dosage,administration time,etc.More clinical research is needed.Secondly,the complex components of Chinese medicinal compounds make it necessary to continuously deepen the exploration of their mechanisms of action,which can provide supportive evidence for the study of oxidative stress in female infertility and the safety of drug use.In addition,human health status and lifestyle are also considered to be important factors affecting oxidative stress.Therefore,in addition to receiving antioxidant treatment,it is also advisable to establish a regular lifestyle and engage in appropriate exercise,which will help the body to exert its antioxidant function.关键词
氧化应激/不孕症/抗氧化治疗/黄体功能不全/子宫内膜异位症/原因不明性不孕症Key words
oxidative stress/infertility/antioxidant therapy/luteal phase defect/endometriosis/unexplained infertility分类
医药卫生引用本文复制引用
王小兰,张海东,周惠芳..氧化应激与不孕症研究进展[J].河南中医,2024,44(7):1121-1127,7.基金项目
国家自然科学基金项目(81973898) （81973898）
江苏省社会发展重大项目(BE2021726) （BE2021726）
江苏省研究生科研与实践创新计划项目(KYCX22_1944) （KYCX22_1944）
