中国实用神经疾病杂志2024，Vol.27Issue(7)：831-836,6.DOI:10.12083/SYSJ.231705
TIA近期进展ACI患者血小板微粒和血清RGMa及CTP参数的变化及意义
Changes and significance of platelet microparticles,serum RGMa and CTP parameters for recent progression to ACI in patients with TIA
摘要
Abstract
Objective To investigate the changes and significance of platelet microparticles,serum repulsive directing molecule a(RGMa)and CT perfusion imaging parameters on transient ischemic attack(TIA)in patients with acute cerebral infarction(ACI).Methods A total of 118 patients with TIA admitted to Hebei Cangzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2020 to June 23 were selected and were divided into ACI group(35 cases)and non-ACI group(83 cases)according to whether ACI occurred.Baseline data,imaging findings,platelet microparticles and serum RGMa levels were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the recent risk factors for ACI progression in TIA patients.The clinical value of platelet microparticles and RGMa in diagnosing recent progression to ACI in patients with TIA was analyzed using receiver operating characteristic(ROC)curve.Results The frequency,duration,platelet particle count and serum RGMa level of TIA in ACI group were significantly higher than those in non-ACI group(P<0.05),CBF and CBV in ACI group were lower than those in non-ACI group(P<0.05),MTT and TTP were higher than those in non-ACI group(P<0.05).Regression results showed that the number of attacks≥3 times,duration≥60 min,decreased CBF and CBV,increased MTT and TTP,high platelet particle count and high serum RGMa level were risk factors for the progression of ACI in TIA patients(P<0.05).ROC results showed that the best cut-off points of platelet microparticles and serum RGMa for recent progression to ACI in TIA patients were 8.84×109/L and 5.22 μg/L,respectively.The sensitivity of platelet microparticles,serum RGMa and CTP detection were 71.43%,74.29%and 80.00%,respectively.The specificity was 91.56%,83.13%,95.18%,the accuracy was 85.59%,80.51%,90.68%,and the AUC was 0.849,0.825,0.912,respectively.Conclusion After TIA patients progressed to ACI,CBF and CBV decrease,while MTT and TTP increase,platelet microcount and serum RGMa levels significantly increase,both of them have certain predictive value for TIA patients to progress to ACI,but the combined detection value is higher.关键词
短暂性脑缺血发作/急性脑梗死/血小板微粒/排斥性导向分子a/CT灌注成像/危险因素/预测价值Key words
Transient cerebral ischemia/Acute cerebral infarction/Platelet microparticles/Repulsive guide molecule a/CT perfusion imaging/Risk factors/Predictive value分类
医药卫生引用本文复制引用
李腾,付厚秀,韩荣坤..TIA近期进展ACI患者血小板微粒和血清RGMa及CTP参数的变化及意义[J].中国实用神经疾病杂志,2024,27(7):831-836,6.基金项目
河北省中医药管理局支撑基金项目(编号:2022248) （编号:2022248）
