健康研究2024，Vol.44Issue(3)：324-327,4.DOI:10.19890/j.cnki.issn1674-6449.2024.03.017
幽门螺杆菌感染对新冠病毒感染的临床表现和转归的影响
The effect of Helicobacter pylori infection on clinical course of SARS-CoV-2 infections
摘要
Abstract
Objective To evaluate the effect of Helicobacter pylori(Hp)on the clinical manifestations and outcomes of SARS-CoV-2 infection.Methods Patients undergoing C14 breath test or rapid urease test for Hp infection in the hospital were selected for investigation.The study aims to understand the clinical presentation of COVID-19 in patients with prior Hp infection,the time frame for significant improvement in symptoms of COVID-19,and to collect data on Hp infection status and basic socio-demographic information of the patients.The survey included the clinical manifestations of SARS-CoV-2,the time to significant symptom improvement among those with a history of SARS-CoV-2 infection,Hp infection status and basic sociodemographic information.Results A total of 502 patients with a history of SARS-CoV-2 infection were surveyed,including 189 Hp-positive and 313 Hp-negative cases.The incidence of abdominal pain(12.2%),abdominal distension(10.1%),and diarrhea(34.9%)in Hp-positive patients were significantly higher than those in Hp-negative patients(5.1%,3.5%,24.3%,respectively),with all differences being statistically significant(P<0.05).Among Hp-negative patients,28.8%had negative conversion of SARS-CoV-2 nucleic acid/antigen within one week,while among Hp-positive patients,only 6.3%had negative conversion within the same period,showing a statistically significant difference(P<0.05);There was no statistically significant differences in the proportion of patients with significant symptom improvement within three days after contracting SARS-CoV-2 between Hp-positive(25.4%)and-negative patients(31.0%)(=1.795,P=0.180).Conclusions Compared to Hp-negative patients,Hp-positive patients had higher rates of abdominal pain,diarrhea,and bloating after contracting SARS-CoV-2.The presence of Hp significantly influenced the time for SARS-CoV-2 antigen or nucleic acid conversion to negative,but did not affect the time for symptom relief.关键词
新冠病毒/幽门螺杆菌/消化系统症状Key words
SARS-CoV-2/Helicobacter pylori/digestive system symptoms分类
医药卫生引用本文复制引用
钟雪晴,王可洋,徐阳,孙逸洁,李国熊..幽门螺杆菌感染对新冠病毒感染的临床表现和转归的影响[J].健康研究,2024,44(3):324-327,4.基金项目
浙江省自然科学基金青年项目(LQ19H030002) （LQ19H030002）
杭州市生物医药和健康产业发展扶持科技专项(2022WJC020) （2022WJC020）
